黄芪多糖：糖尿病预防的有效治疗方法。

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Exp Clin Endocrinol Diabetes. 2008 Aug;116(8):468-74.

Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice.

Chen W¹, Li Y-, Yu M-.

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Abstract

BACKGROUND:

Type 1 diabetes mellitus (DM) is a chronic autoimmune disease that is related to the disequilibrium state of Th1 and Th2 subgroups of helper T lymphocyte (Th) and their cytokines. Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of human immune system.

OBJECTIVE:

To investigate the effects of APS on preventing type 1 DM and Th1/Th2-subtype cytokines, we compared the results of administration of APS and normal saline (NS) on non-obese diabetic (NOD) mice.

SUBJECTS AND METHODS:

APS or NS was administered to 4-week-old mice at a dose of 2.0 g/kg per day for 10 weeks. At 40 weeks, blood glucose, serum C-peptide (C-P) and GAD antibody were measured; pancreas was examined histologically; the intra-islet lymphocyte infiltration and T lymphocyte subsets in the spleen were analysed; the gene expression of IL-1 beta, IL-2, IL-6, IL-12, TNF-alpha, INF-gamma, IL-4, IL-5, IL-10, TGF-beta, Bcl-2, SOD, Fas and iNOS were measured by RT-PCR.

RESULTS:

The results showed that APS-administered NOD mice had a lower incidence rate of type 1 DM, lower serum C-P level, better histologic findings of pancreatic islets, and a lower D4+/CD8+ ratio of T lymphocytes from the spleen and the infiltrated islets. RT-PCR analysis showed gene expression levels are lower in IL-1 beta, IL-2, IL-6, IL-12, TNF-alpha, INF-gamma, Fas, iNOS, and higher in IL-4, IL-5, IL-10, TGF-beta, Bcl-2, SOD in the pancreatic tissue from APS-administered NOD mice as compared to the NS group.

CONCLUSIONS:

These results demonstrated the effects of Astragalus polysaccharides on the prevention of type 1 DM in NOD mice by correcting the imbalance between the Th1/Th2 cytokines.

https://www.ncbi.nlm.nih.gov/pubmed/18924264

所有跟帖： 

• 支持御醫的分享 -Lilac2003- ♀ (0 bytes) () 07/07/2017 postreply 08:12:05

• 这个黄芪多糖比黄芪泡水还好吗？夏天可以吃吗？ -claude888- ♂ (0 bytes) () 07/07/2017 postreply 11:12:54

• 搜索,御醫高見都在here -Lilac2003- ♀ (171 bytes) () 07/07/2017 postreply 11:38:45

• 谢谢 -claude888- ♂ (0 bytes) () 07/07/2017 postreply 13:42:34

• 有的人喝黄芪片会上火。。。 -御用文人- ♀ (332 bytes) () 07/07/2017 postreply 12:40:04

• 谢谢 -claude888- ♂ (0 bytes) () 07/07/2017 postreply 13:42:51

• 那里生产的？很怕里面掺其他西药成分。 -goingplace- ♀ (0 bytes) () 07/07/2017 postreply 11:30:24

• Now 是一个好品牌 -Lilac2003- ♀ (0 bytes) () 07/07/2017 postreply 11:40:06

• 想种这个，英文叫啥？也叫Astragalus polysaccharides 吗？ -xiaoxiao2013- ♀ (0 bytes) () 07/07/2017 postreply 12:17:21

• Astragalus membranaceus or Astragalus mongholicus -御用文人- ♀ (0 bytes) () 07/07/2017 postreply 12:27:44

• thanks :) -xiaoxiao2013- ♀ (0 bytes) () 07/07/2017 postreply 13:51:13