The idea that having the gallbladder removed affects the risk of colon cancer was explored in a study of nearly 56,000 patients in Great Britain’s General Practice Research Database. The investigators, from the University of Pennsylvania, found a very small increased risk of colon cancer among these patients. Their data suggested that of every 10,000 patients who had their gallbladders removed, 119 would develop colon cancer within 10 years. That compares to a slightly lower rate of colon cancer among the same number of British patients in this study who didn’t have gallbladder surgery: 86 of them developed colon cancer in the same period of time. No higher risk of rectal cancer was seen among the patients who had gallbladder surgery. The study was published in the August, 2005, issue of the American Journal of Gastroenterology.