输进去的白蛋白在血管里的半衰期只有15小时

来源: 志在千里 2015-05-14 23:13:27 [] [旧帖] [给我悄悄话] 本文已被阅读: 次 (968 bytes)
http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/UCM211622.pdf
The distribution of exogenous albumin between body compartments has been examined by the injection of radio-labeled albumin. Over the first 2 days, there is a rapid phase of disappearance from the plasma that correlates with the transcapillary exchange rate of 4.5% per hour. The distribution half-time is about
15 hours. Then there is a slower decay of about 3.7% per day with an elimination half time ofabout 19 days.

Albumin is distributed throughout the extracellular compartments, more than
60% of the body albumin pool is located in the extravascular fluid compartment.
The total body albumin in a 70 kg man is estimated to be 350g, it has a half live
of about 13-19 days with a turnover of approximately 15g per day.[2-41

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谢谢分享。原来白蛋白还会快速离开血液进入细胞间液。 -欲千北- 给 欲千北 发送悄悄话 欲千北 的博客首页 (0 bytes) () 05/15/2015 postreply 05:23:59

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