天然产物作为抗癌药的主要来源:

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Thus, in the area of cancer, over the time frame from around the 1940s to date, of the 175 small molecules, 131 or 74.8% are other than “S” (synthetic), with 85 or 48.6% actually being either natural products or directly derived there from.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721181/

The chart below is for all drugs:



Major Categories of Sources

The major categories used are as follows:

  • “B” Biological; usually a large (>45 residues) peptide or protein either isolated from an organism/cell line or produced by biotechnological means in a surrogate host.
  • “N” Natural product.
  • “NB” Natural product “Botanical” (in general these have been recently approved).
  • “ND” Derived from a natural product and is usually a semi-synthetic modification.
  • “S” Totally synthetic drug, often found by random screening/modification of an existing agent.
  • “S*” Made by total synthesis, but the pharmacophore is/was from a natural product.
  • “V” Vaccine.


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