When the mean value of blood glucose increased from 100 to 400 m

American Journal of Hypertension 14, 433-438 (May 2001) | doi:10.1016/S0895-7061(00)01260-7

• ARTICLE TOOLS

  • Send to a friend
  • Export citation
  • Rights and permissions
  • Order commercial reprints
  • Bookmark in Connotea

• SEARCH PUBMED FOR

  • Yildirim Çinar
  • A. Mete Şenyol
  • Kamber Duman

Blood viscosity and blood pressure: role of temperature and hyperglycemia

Yildirim Çinar, A. Mete Şenyol and Kamber Duman

Abstract

We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman's correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased 26.13%. This increase resulted in a 20.72% decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was 20.72%. Also, a 34.73% decrease in erythrocyte deformability and 18.71% increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased 10.38%. This caused 11.15% decrease in blood flow rate, and 11.15% decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = −0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP.

To read this article in full you may need to log in, make a payment or gain access through a site license (see right).

所有跟帖： 

• Viscosity Increased 25% (r = 0.59, P = .002). -qiuqiu04.- ♂ (0 bytes) () 12/12/2011 postreply 19:31:36

• 说一句题外话，不要见怪哟。 -恶俗老狼- ♂ (164 bytes) () 12/12/2011 postreply 19:40:15

• 那么高的血糖,心血管受损肯定很厉害.所以那种观察更有可能是结果而不是原因. -weston- ♀ (0 bytes) () 12/12/2011 postreply 23:05:57

• 我是针对那个研究报告里观察到的事实:在血糖达到400mg/dl时,流动性减低25% -weston- ♀ (100 bytes) () 12/13/2011 postreply 09:48:58

• At 400 mg/dl, a lot of damage is already done. So the conclusio -weston- ♀ (0 bytes) () 12/12/2011 postreply 19:45:10