如果是我,会服用维生素C。

来源: 欲千北 2022-01-14 22:38:39 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读: 次 (3521 bytes)
回答: 孩子和我都得了新冠,Stella992022-01-14 21:00:05

(机器翻译)   维生素 C 是人类必需的微量营养素,具有与其提供电子的能力相关的多效性功能。它是一种有效的抗氧化剂,也是生物合成和基因调控酶家族的辅助因子。维生素 C 通过支持先天和适应性免疫系统的各种细胞功能来促进免疫防御。维生素 C 支持针对病原体的上皮屏障功能,并促进皮肤的氧化剂清除活性,从而潜在地防止环境氧化应激。维生素 C 在吞噬细胞(如嗜中性粒细胞)中积累,可增强趋化性、吞噬作用、活性氧的产生,并最终杀死微生物。它也是巨噬细胞感染部位消耗的中性粒细胞凋亡和清除所必需的,从而减少坏死/NETosis 和潜在的组织损伤。维生素 C 在淋巴细胞中的作用尚不清楚,但已显示它可以增强 B 细胞和 T 细胞的分化和增殖,这可能是由于其基因调节作用。维生素C缺乏会导致免疫力受损和更易感染。反过来,由于炎症和代谢需求的增加,感染会显着影响维生素 C 的水平。此外,补充维生素 C 似乎能够预防和治疗呼吸道和全身感染。预防感染需要膳食维生素 C 摄入量,如果不能达到饱和血浆水平(即 100-200 毫克/天),至少可以提供足够的血浆水平,从而优化细胞和组织水平。相反,治疗既定感染需要显着更高(克)剂量的维生素来补偿增加的炎症反应和代谢需求。


Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Prophylactic prevention of infection requires dietary vitamin C intakes that provide at least adequate, if not saturating plasma levels (i.e., 100–200 mg/day), which optimize cell and tissue levels. In contrast, treatment of established infections requires significantly higher (gram) doses of the vitamin to compensate for the increased inflammatory response and metabolic demand.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/ 

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