怀孕时吸入污染空气增加孩子神经母细胞瘤（癌症）的风险

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Environ Res. 2013 Nov;127:1-6. doi: 10.1016/j.envres.2013.09.002. Epub 2013 Oct 16.

An exploratory study of ambient air toxics exposure in pregnancy and the risk of neuroblastoma in offspring.

Heck JE¹, Park AS, Qiu J, Cockburn M, Ritz B.

Author information

• ¹Department of Epidemiology, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA 90095-1772, USA. Electronic address: [e-mail].

Abstract

Little is known about the etiology of neuroblastoma, the most common cancer in infancy. In this study, we examined maternal exposure to ambient air toxics in pregnancy in relation to neuroblastoma in the child. We ascertained all cases of neuroblastoma listed in the California Cancer Registry 1990-2007 that could be linked to a California birth certificate, and controls were selected at random from California birth records. Average air toxics exposures during pregnancy were determined based upon measures from community-based air pollution monitors. The study included 75 cases and 14,602 controls who lived with 5 km of an air pollution monitor, and we additionally examined results for those living within a smaller radius around the monitor (2.5 km). Logistic regression was used to determine the risk of neuroblastoma with one interquartile range increase in air toxic exposure. Neuroblastoma risk was increased with higher maternal exposure to carbon tetrachloride (OR=2.65, 95%CI 1.07, 6.53) and polycyclic aromatic hydrocarbons (OR=1.39, 95%CI 1.05, 1.84), particularly indeno(1,2,3-cd)pyrene and dibenz(a,h)anthracene. Hexavalent chromium was associated with neuroblastoma at the 5 km distance (OR=1.32, 95%CI 1.00, 1.74) but not at the 2.5 km distance. This is one of the first studies to report associations between neuroblastoma and these air toxics.

© 2013 Elsevier Inc. All rights reserved.

所有跟帖： 

• 个人认为可能是四氯化碳和多环芳烴损害或延迟了新生儿的免疫系统的发育，无法靠自身的免疫力阻止视网膜母细胞瘤细胞繁衍。 -御用文人- ♀ (0 bytes) () 03/05/2015 postreply 22:54:52

• 正常新生儿本身就存在视网膜母细胞瘤的变异细胞，到2岁以后这些视网膜母细胞瘤细胞会自动消失。 -御用文人- ♀ (0 bytes) () 03/05/2015 postreply 22:58:00

• 因其他原因死亡的新生儿，在尸检中常常被发现存在着视网膜母细胞瘤细胞。两岁以后自动消失。 -御用文人- ♀ (0 bytes) () 03/06/2015 postreply 09:37:36

• 这说明，新生儿的免疫系统本来就不健全。而空气污染可能起着妨碍新生儿免疫系统发育的作用。 -御用文人- ♀ (0 bytes) () 03/06/2015 postreply 09:39:54

• 至少从这个现象可以得出一个结论，空气污染的确会增加癌症发病率。至于癌症的病因，不同的癌症具有不同的致癌因素。 -御用文人- ♀ (60 bytes) () 03/06/2015 postreply 10:12:33

• 谢谢！ 是的空气污染孩子最受苦。 -志在千里- ♀ (0 bytes) () 03/06/2015 postreply 22:14:39