美国研究人员已找到人类乳突病毒（HPV）感染与心脏疾病间的关联。这项研究的受试妇女皆无其他风险因子，报告结果在昨天发表，为这类型研究之首。
尽管这项研究尚属早期阶段，专家表示若经证实，将可为对抗心脏疾病提供新方法。心脏疾病为大部分国家的妇女头号杀手。
德克萨斯州大学医学分校（University of Texas Medical Branch）心脏内科（Division of Cardiology）主任藤濑（Ken Fujise）说：〝近20%心血管疾病患者没有显现任何风险因子，显示‘非传统’成因可能隐含在内。〞
藤濑说：〝HPV似乎是女性1项危险因子。〞
研究人员会想到调查HPV为潜在心脏疾病风险，是因为其抑制p53及pRb两种肿瘤抑制基因、引发癌症。p53是调节动脉粥状硬化过程的关键基因；pRb则是调节细胞周期的重要因素。
同样来自UTMB的研究共同作者郭绪格（Hsu-Ko Kuo，译音）表示，尽管研究人员尚未证实HPV与心脏疾病的关联性，但的确发现〝致癌HPV类型与心脏疾病的强烈相关〞。研究对象为2500名20至59岁女性。
研究将刊于11月1日号的〝美国心脏病学会期刊〞（Journal of the American College of Cardiology）。
HPV是最普遍的性传染病，类型逾40种，部分可导致子宫颈癌或尖形湿疣，但大多数时候HPV不会出现任何症状。
Women who carry the human papillomavirus (HPV) have an increased risk of heart disease, a new study finds.
Women who tested positive for any of the 37 strains of the virus the researchers tested for were 2.3 times more likely to also have had either a heart attack or stroke than women who tested negative, the study found. And women who tested positive for either of the two strains associated with cervical cancer had 2.86 times the risk of heart attack or stroke, according to the study.
As such, the study suggests that "the HPV vaccine may also help prevent heart disease," said lead author Dr. Ken Fujise, director of cardiology at the University of Texas Medical Branch at Galveston.
Nearly 20 percent of people who develop heart disease do not have any known risk factors, such as smoking or high blood pressure, which indicates that other "nontraditional" causes may be involved. "HPV appears to be one such factor among women," Fujise said.
Still, women with HPV should not worry because "this is very first study to link HPV with [heart disease],” Fujise said. Longitudinal studies, which follow patients over time, are needed to confirm the link between HPV and heart disease. "However, our data suggests those patients should be followed more closely by their doctors — if [they] have chest pain, take it very seriously," he said.
The study will be published on Nov. 1 in the Journal of the American College of Cardiology.
HPV and heart disease
The study included nearly 2,500 women between the ages of 20 and 59; the researchers gathered data from the National Health and Nutrition Examination Survey, conducted by the Centers for Disease Control and Prevention between 2003 and 2006.
Among the study participants, 44.6 percent tested positive for HPV, including 23.2 percent who had the cancer-causing strains of the virus. Other studies have found that the virus is found in between 20 percent and 45 percent of people in the general population, Fujise said.
Of the 60 women in the study who reported they'd had either a heart attack or stroke, 39 tested positive for any HPV strain, and 21 tested negative.
"I thought there would be a weak link between HPV and cardiovascular disease, but I didn't expect [the risk] to be 2.3 times as high," Fujise said.
The study showed that for every 55 women with HPV, one woman is likely to have a heart attack or stroke because of the virus, rather than because of other risk factors, Fujise said.
Every year, 510,000 U.S. women have heart attacks, according to the American Heart Association. If the study's findings hold up in larger studies, Fujise calculated that would mean that 4,321 of these women are having heart attacks due to HPV, rather than other risk factors; and 1,618 women die yearly from these HPV-related heart attacks.
How a virus might cause a heart attack
The researchers said the link might be due to the virus's ability to silence two genes known to play roles in the health of blood vessels. The two genes, called p53 and retinoblastoma protein, both work to suppress the growth of tumors. Atherosclerosis, which is the thickening of artery walls, is also regulated by p53, while the retinoblastoma gene regulates the growth of smooth muscle cells that line blood vessels, and so could impact blood flow.
"We didn't study males, but men can be infected with HPV. Our next hypothesis is that maybe male HPV vaccinations would protect men from heart attacks and stroke," Fujise said.
If researchers find the exact mechanism by which HPV causes heart attacks and stroke, they could look for a drug that could treat people infected with the virus to lower their risk, he said.
Pass it on: Women with HPV may have a higher risk of heart disease.
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