1.以下链接是对Laetrile的来龙去脉的最详细介绍:
http://www.quackwatch.org/01QuackeryRelatedTopics/Cancer/laetrile.html
Scientific Review
One of the first practitioners to use Laetrile was Arthur T. Harris, M.D., who had trained in Scotland and reportedly studied embryology under John Beard. Harris, who had been doing family practice in Southern California, renamed his office the Harris Cancer Clinic. Within a year he submitted a report to Coronet Magazine which claimed that he was "working on something out here that is going to be the answer to cancer if there will ever be one," but the magazine did not report what he was doing.
By that time, the California Medical Association was receiving inquiries about Laetrile. When members of its Cancer Commission approached Krebs, Sr., he claimed that "limited" trials of toxicity in animals had been performed with satisfactory results, but that the records had been destroyed. No human trials involving Laetrile had been undertaken, but the Commission was offered case reports of patients in which spectacular results had supposedly been observed. However, the details claimed by the Krebs team could not be confirmed by other sources. The Commission was able to obtain a small supply of Laetrile for animal tests at three medical centers—all of which produced negative results.
At one point, the Krebs' agreed to supply Laetrile for a controlled clinical investigation at Los Angeles County Hospital. But later they said they would do so only if a Laetrile advocate were put in charge—which was not acceptable to hospital authorities. The Commission then evaluated the records of 44 patients treated according to the Krebs' recommendations. Two years had elapsed since the first of these patients had been treated with Laetrile. Nineteen had already died and there was no evidence that Laetrile had helped any of the others.
Victims in the News
As Laetrile became newsworthy, several cancer victims treated with it drew widespread media scrutiny. One was Chad Green, who developed acute lymphocytic leukemia at age 2. Although he was rapidly brought into remission with chemotherapy, his parents started him on "metabolic therapy" administered by a Manner Metabolic Physician. When Chad developed signs of cyanide toxicity, Massachusetts authorities had him declared a ward of the court for treatment purposes only. His parents then brought suit to reinstitute "metabolic therapy." When the court ruled against them, they fled with Chad to Mexico, where he was treated by Dr. Contreras. Several months later Chad died in a manner suggestive of cyanide poisoning. Dr. Contreras stated that the boy had died of leukemia, but was a good example of the effectiveness of Laetrile because he had died a pleasant death! Chad's parents stated that he had become very depressed because he missed his grandparents, his friends and his dog.
Joseph Hofbauer was a 9-year-old with Hodgkin's disease. Unlike Chad Green's parents, Joseph's parents never allowed him to receive appropriate treatment but insisted that he receive Laetrile and "metabolic therapy." When New York State authorities attempted to place him in protective custody, his parents filed suit and convinced family court judge Loren Brown to let the parents make the treatment decision. Brown stated that "This court also finds that metabolic therapy has a place in our society, and hopefully, its proponents are on the first rung of a ladder that will rid us of all forms of cancer." The parwents rejected standard treatment, and Joseph died of his disease two years later. Acute lymphocytic leukemia and Hodgkin's disease both have a 95% 5-year survival rate with appropriate chemotherapy.
During 1980, movie star Steve McQueen attracted considerable attention when he was treated with Laetrile at another Mexican clinic under the supervision of William D. Kelley, a dentist who had been delicensed by the State of Texas after several brushes with state and federal law enforcement authorities. Although McQueen gave a glowing report when he began his treatment, he died shortly afterward.
......一些法律方面的介绍:
Recent Enforcement Actions
- On April 20, 2000, the U.S. Justice Department obtained a preliminary injunction barring Christian Bros. Contracting Corp., of Whitestone, New York, and its president, Jason Vale from making or distributing amygdalin, Laetrile, "Vitamin B-17," or apricot seeds [11]. Although Vale signed a consent decree, he continued his sales activity through a network of Internet sites, toll-free telephone numbers, and shell companies. In 2003, a federal jury in Brooklyn found him guilty of criminal contempt [12] for which he was sentenced to prison.
- In July 2000, Kenneth N. Michaelis and his company, Holistic Alternatives, both of Louisville, Ohio, were indicted for conspiring to distribute Laetrile and hydrazine sulfate in interstate commerce. The indictment also alleged that with intent to mislead the FDA, the defendants failed to register their drug manufacturing facility [13]. The company, which defied the FDA for many years, described itself as "the oldest supplier of laetrile and hydrazine sulfate in the US." In 2001, Michaelis pleaded guilty and was fined $10,000 and sentenced to six months in prison followed by a year of supervised release. He also agreed to a permanent injunction. After reviewing the relevant documents, the Ohio State Medical Board suspended Michaelis's massage therapy license for at least 180 days and issued terms under which he could apply for instatement [14].
- On September 1, 2000, a United States District Court Judge issued a preliminary injunction against World Without Cancer, Inc., The Health World International, Inc. of Bay Harbor Island, Health Genesis Corporation, an Arizona concern that does business in Bay Harbor Island, Florida, and David E. Arizona, an officer of the three corporations. The ruling enjoins the defendants from introducing or causing the introduction into interstate commerce of laetrile products, apricot seeds, or any other unapproved drug product as well as manufacturing, processing, packing, labeling, promoting, or distributing these or any other new drug. The order also requires the defendants to modify their Internet web sites to cease using the web sites to promote the sale of or offer for sale their laetrile products [15].
- In January 2004, Jack Edwin Slingluff, D.O., of Canton, Ohio, pled guilty to one count of introducing an unapproved new drug into interstate commerce [16]. The one-count criminal information stated that he "caused thirty (30) vials of the unapproved new drug Amigdalina B-17 (AKA Laetrile) to be shipped from West Palm Beach, Florida, to Salem, Ohio; in violation of Title 21, Sections 331(d), 355(a) and 333(a)(1), United States Code." The State Medical Board of Ohio suspended his medical license for a year and permanently revoked it in 2008 [17]. He died in 2011.
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2. 
英国癌研所和American Cancer Society的介绍:
Laetrile (amygdalin, vitamin B17) : Cancer Research UK ...
Laetrile - American Cancer Society
英国癌研所的提醒：
A word of caution
Only you can decide whether or not to use alternative cancer therapies such as laetrile. But we recommend that you don't use any alternative therapies, including laetrile, instead of conventional treatment. If you have cancer, using unproven methods instead of conventional medical treatment can seriously harm your health.
Many internet sites advertise and promote laetrile as a treatment to cure cancer. But no reputable scientific cancer organisations support any of these claims. Our advice is to be very cautious about believing this type of information or paying for any alternative cancer therapy over the internet.
We are concerned that products are marketed as potential cures. They are often sold for a great deal of money, when they lack scientific evidence to prove that they help. And they could also cause harm.
It is understandable that you and the people close to you will want to try anything if you think it might help treat or cure your cancer. So our message is to
- Be very careful
- Make sure that you look into all the information available, and check who provides it
- Talk to your cancer doctor before you spend money for any therapy, whether it’s conventional, complementary or alternative
Where to find more information
Our section about complementary and alternative therapies is a useful place to start for general information about complementary and alternative therapies in cancer care. The complementary therapy organisations and websites may be able to offer more information about laetrile. There is detailed information on the CAM-cancer website.
3. 推崇Laetrile治疗者的有良心的（可贵的）提醒:
Laetrile / Vitamin B17 - Alternative Cancer Treatment
以Raw Food Diet 开始: The Raw Food Diet
注意事项:
IT IS CRITICAL to take the pancreatic or proteolytic enzymes during the laetrile therapy!!
Warning #1 – Laetrile May Cause Low Blood Pressure
This is an important message I received by email: “Laetrile ingestion may occasionally cause a temporary low blood pressure reaction due to formation of thiocyanate, a powerful blood pressure lowering agent. In metabolism, nitriloside is hydrolyzed to free hydrogen cyanide, benzaldehyde or acetone and sugar. This occurs largely through the enzyme beta-glucosidase produced by intestinal bacteria as well as by the body. The released HCN [hydrocyanide] is detoxified by the enzyme rhodanese to the relatively non-toxic thiocyanate molecule.”
Normally, lowering blood pressure is not an issue, however, for those who are already taking blood pressure medications, or have heart issues which would be made worse by a drop in blood pressure, be advised that laetrile can lower blood pressure.
Warning #2 – Proteolytic Enzymes are Blood Thinners
Because many people on laetrile also use proteolytic enzymes (i.e. pancreatic enzymes), it is important to know that proteolytic enzymes are blood thinners. Proteolytic enzymes, such as Vitalzym, should NOT be used in conjunction with prescription blood thinners unless the medical doctor understands they are being used.
For example, when my wife added 10Zymes to her daily pills, the doctor reduced the amount of prescription blood thinners she was taking. That is good because prescription blood thinners can cause hardening of the arteries. However, the Pro Time test must be used shortly after any change in pills.
Also, high doses of proteolytic enzymes should not be taken, just as too high of a dose of any blood thinner should never be taken. See the bottle for maximum doses.
Warning #3 – Do Not Take Laetrile With Probiotics
From an email: “It was our experience that taking laetrile with high strength probiotics may also increase the amount of free hydrogen cyanide and thus could create adverse side effects.”
Warning #4 – Using Laetrile With the Bob Beck Protocol
If you plan on using the Bob Beck Protocol (an electromedicine treatment) and laetrile at the same time, do NOT take any laetrile until you are finished with both of the Bob Beck Protocol electromedicine devices (e.g. the blood purifier and magnetic pulser) for the day. In other word, when you are finished using the Bob Beck Protocol for the day, take your laetrile. This gives the laetrile plenty of time to be absorbed by the body before starting the Bob Beck Protocol on the next day.
If you are taking apricot kernels, take no more than one-third of the daily number of kernels before the Bob Beck Protocol is finished for the day.
Warning #5 – Combining Laetrile With Other Alternative Cancer Treatments
Whenever a person combines two or more alternative cancer treatments together, it is critical to do your homework. For example, Vitamin C should be taken with laetrile, however, Vitamin C should not be taken with Protocel, graviola (e.g. Amazon Factor Protocol), hydrazine sulfate, etc.
In other words, if you are taking a second or third alternative cancer treatment with laetrile, or if laetrile is being used to supplement another treatment, be careful to watch the warnings on each treatment.
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