【糖尿病 降糖药】

 

Sodium-glucose Cotransporter-2  (SGLT2)  Inhibitors

SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin. They are available as single-ingredient products and also in combination with other diabetes medicines such as metformin. SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine. 

The following drugs belong to the SGLT2 inhibitors class (trade name first, generic name in brackets):

• Forxiga (Dapagliflozin)
• Invokana (Canagliflozin)
• Jardiance (Empagliflozin)

 

How do SGLT2 inhibitors work?

SGLT2 inhibitors work by preventing the kidneys from reabsorbing glucose back into the blood.

 

 Common side effects of Jardiance include:

• dehydration,
• dizziness,
• lightheadedness,
• weakness,
• yeast infection,
• low blood sugar,
• nausea,
• upper respiratory tract infection,
• high cholesterol,
• joint pain,
• increased urination,
• urinary tract infection,
• thirst, and
• low blood pressure (hypotension).

The recommended dose of Jardiance is 10 mg once daily in the morning, taken with or without food.