【糖尿病II型 的家族遗传特征】

 

 

"this disease is transmitted as a recessive genetic characteristic." 

 

Type 2 diabetes and genetics

Key points

1. 1，If both of your parents have type 2 diabetes, you have a 50 percent chance of developing the disease.,
2. 2，Having a hereditary risk doesn’t mean you’ll definitely develop the condition.
3.  
4.  

Diabetes is a complex condition. Several factors must come together for you to develop type 2 diabetes. For example, obesity and a sedentary lifestyle play a role. Genetics can also influence whether you’ll get this disease.

If you’ve been diagnosed with type 2 diabetes, there’s a good chance that you’re not the first person with diabetes in your family. According to theAmerican Diabetes Association, your risk of developing type 2 diabetes is:

1. 1 in 7 if one of your parents was diagnosed before the age of 50
2. 1 in 13 if one of your parents was diagnosed after the age of 50
3. 1 in 2, or 50 percent, if both your parents have diabetes

 

In general, mutations in any gene involved in controlling glucose levelscan increase your risk of type 2 diabetes. These include genes that control:

• production of glucose
• production and regulation of insulin
• how glucose levels are sensed in the body

Genes associated with type 2 diabetes risk include:

• TCF7L2, which affects insulin secretion and glucose production
• ABCC8, which helps regulate insulin
• CAPN10, which is associated with type 2 diabetes risk in Mexican-Americans
• GLUT2, which helps move glucose into the pancreas
• GCGR, a glucagon hormone involved in glucose regulation

 

1. http://www.healthline.com/health/type-2-diabetes/genetics#genes3