1， Age and female sex — Increasing age and female sex are important risk factors for gallstones. The prevalence of gallstones is higher in females as compared with males in all age groups
2，Genetic susceptibility — Family history studies suggest that genetics has a significant role in the development of gallstones
3，Diabetes mellitus — Diabetes mellitus is associated with an increased risk of cholesterol gallstones
4，Dyslipidemia — Elevated non-high density lipoprotein (non-HDL) cholesterol may be a risk factor for gallstones （这个是可以调整的risk factor）
5，Diet and lifestyle factors： Obesity Rapid weight loss 等 （这个是可以调整的risk factor）
Obesity — Obesity is an established risk factor for the development of cholesterol gallstones, presumably due to enhanced cholesterol synthesis and secretion
6，Medications：Medications — Several drugs can promote the formation of gallstones：）
