【笑坛文工团四周年庆】诺奖得主与牛奶：有结果了！（非笑贴）

来源: 久经沙场的枪于 2021-05-01 00:40:20 [档案] [博客] [旧帖] [给我悄悄话] 阅读数 : (34208 bytes)

本帖于 2021-05-01 00:42:16 时间, 由普通用户久经沙场的枪编辑

2019年我介绍了诺奖得主Prof. zur Hausen的研究领域：诺奖得主与牛奶

今年果不其然，有结果了。

向zur Hausen教授致敬！

牛奶和牛肉间接致癌的原因：它们携带有一种新型病原体

生物世界

2021/03/26

论文

论文标题：Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions

作者：Timo Bund, Ekaterina Nikitina, Deblina Chakraborty, Claudia Ernst, Karin Gunst, Boyana Boneva, Claudia Tessmer, Nadine Volk, Alexander Brobeil, Achim Weber, Mathias Heikenwalder, Harald zur Hausen, Ethel-Michele de Villiers

期刊：PNAS

发表时间：2021/03/23

数字识别码：10.1073/pnas.2025830118

摘要：Consumption of Eurasian bovine meat and milk has been associated with cancer development, in particular with colorectal cancer (CRC). In addition, zoonotic infectious agents from bovine products were proposed to cause colon cancer (zur Hausen et al., 2009). Bovine meat and milk factors (BMMF) are small episomal DNA molecules frequently isolated from bovine sera and milk products, and recently, also from colon cancer (de Villiers et al., 2019). BMMF are bioactive in human cells and were proposed to induce chronic inflammation in precancerous tissue leading to increased radical formation: for example, reactive oxygen and reactive nitrogen species and elevated levels of DNA mutations in replicating cells, such as cancer progenitor cells (zur Hausen et al., 2018). Mouse monoclonal antibodies against the replication (Rep) protein of H1MSB.1 (BMMF1) were used to analyze BMMF presence in different cohorts of CRC peritumor and tumor tissues and cancer-free individuals by immunohistochemistry and Western blot. BMMF DNA was isolated by laser microdissection from immunohistochemistry-positive tissue regions. We found BMMF Rep protein present specifically in close vicinity of CD68+ macrophages in the interstitial lamina propria adjacent to CRC tissues, suggesting the presence of local chronic inflammation. BMMF1 (modified H1MSB.1) DNA was isolated from the same tissue regions. Rep and CD68+ detection increased significantly in peritumor cancer tissues when compared to tissues of cancer-free individuals. This strengthens previous postulations that BMMF function as indirect carcinogens by inducing chronic inflammation and DNA damage in replicating cells, which represent progress to progenitor cells for adenoma (polyps) formation and cancer.

所属学科：

免疫学

生物

图片来源：Cats Coming from Pexels

撰文 | 王聪

编辑 | nagashi

排版 | 水成文

哈拉尔德·楚尔·豪森（Harald zur Hausen），德国著名科学家，曾发现某些类型的乳头状瘤病毒（HPV）就是宫颈癌的病原体，为开发出宫颈癌疫苗打下了基础，因此获得了2008年的诺贝尔生理学或医学奖。

早在10多年前，诺贝尔奖得主楚尔·豪森就曾通过大数据发现，食用牛肉和牛奶与癌症发展有关，尤其是结直肠癌。楚尔·豪森认为，可能是牛肉和牛奶中含有的病原体导致了癌症。

几年前，德国癌症研究中心的 De Villiers 领导的研究团队在乳制品和牛血清中发现了一种新型的病原体，这种病原体是一种环状DNA，与某些细菌质粒的基因序列显示出极大的相似性。由于它们来源于牛肉和牛奶，因此研究团队将其命名为BMMF（Bovine Meat and Milk Factors，牛肉和牛奶因子）。

那么，在乳制品和牛血清中发现的新型传染因子BMMF是否在结直肠癌的发生中起作用呢？为了搞清楚这个问题，楚尔·豪森与 De Villiers 展开合作。

2021年3月15日，楚尔·豪森与 De Villiers 团队在《美国科学院院刊》（PNAS）发表了题为：Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions 的研究论文。

研究团队在结肠癌患者的肿瘤附近细胞中发现了BMMF（牛肉和牛奶因子）的存在，并进一步发现BMMF会触发局部慢性炎症，这种慢性炎症导致活性氧（ROS）水平升高，进而引发基因突变，从而长期促进癌症发生发展。

该研究支持了牛奶和牛肉的消费与结直肠癌的发展有因果关系，研究团队还表示，BMMF应当被视为间接致癌物，对于早期检测到存在BMMF的人，他们应及时进行结直肠癌筛查。