Vicinium Represents New Treatment Option for Non- Muscle Invasiv

https://news.cancerconnect.com/bladder-cancer/vicinium-represents-new-treatment-option-for-non-muscle-invasive-bladder-cancer-GYXbbNePkkqlyo46SXpwIg

ASCO Update in 09/2019:

Today three-month data from the ongoing Phase 3 VISTA Trial of Vicinium™ for the treatment of patients with high-grade non-muscle invasive bladder cancer (NMIBC) who have been previously treated with bacillus Calmette-Guérin (BCG) were released. Overall 43% of patients achieved a complete response and Vicinium appears to represent an emerging treatment option.

About Vicinium™

Vicinium™, also known as VB4-845, is an antibody-drug conjugate (ADC), developed for the treatment of high-grade non-muscle invasive bladder cancer (NMIBC). Vicinium is comprised of a recombinant fusion protein that targets epithelial cell adhesion molecule (EpCAM) antigens on the surface of tumor cells to deliver a potent protein payload, Pseudomonas Exotoxin A (ETA). EpCAM has been shown to be overexpressed in NMIBC cells with minimal to no EpCAM expression observed on normal bladder cells.