For women with a mutation in one of these genes, the lifetime risk of having ovarian, tubal or peritoneal cancer is 39-46% in BRCA1 mutation carriers and 12-20% in BRCA2 mutation carriers.
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Genetics: BRCA1 and BRCA2
About 20 to 25 percent of women diagnosed with ovarian cancer have a hereditary tendency to develop the disease. The most significant risk factor for ovarian cancer is an inherited genetic mutation in one of two genes: breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2). These genes are responsible for about 10 to 15 percent of all ovarian cancers.
Eastern European women and women of Ashkenazi Jewish descent are at a higher risk of carrying BRCA1 and BRCA2 mutations.
Since these genes are linked to both breast and ovarian cancer, women who have had breast cancer have an increased risk of ovarian cancer. You can find more detail about BRCA1 and BRCA2 mutations in the Ovarian Cancer Risk Consensus Statement—BRCA1 and BRCA2, which the Alliance endorsed in 2012.
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BRACAnalysis CDx Infographic
