Preliminary results from a small clinical trial of a new drug, Cabozantinib
(XL184) have shown unprecedented response rates: Bone metastases
improved in 85% of patients with castration-resistant prostate cancer
(CRPC) who completed the 12 week lead-in period. Another 13% had
stable disease resulting in an overall rate of bone disease control of
98%. Of 43 evaluable patients with bone pain, 26 (60%) had measurable
improvement with reduced pain as early as six weeks after starting
cabozantinib.