大麻的毒性被恶魔化了。纯学术观点。不是推荐大家吸

来源: 2021-12-29 07:09:11 [博客] [旧帖] [给我悄悄话] 本文已被阅读:

下面的这张图应该是权威的意见。

 

 

 

 

英国医学杂志《柳叶刀》2007年刊文数据显示,大麻(Cannabis)对身体的伤害(Physical Harm)和依赖性(Dependence)都不如烟草(Tobacco)和酒精(Alcohol)

 

 

 

[28] Blakemore, Colin; Saulsbury, William; King, Leslie A.; Nutt, David (24 March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse"The Lancet369 (9566): 1047–1053. doi:10.1016/S0140-6736(07)60464-4ISSN 0140-6736PMID 17382831S2CID 5903121.

 

Reference: Nature的文章,我没读。

https://www.nature.com/articles/srep08126.pdf

 

A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg bodyweight for heroin to 531 mg/kg bodyweight for alcohol (ethanol). For individual exposure the four substances alcohol, nicotine, cocaine and heroin fall into the ‘‘high risk’’ category with MOE , 10, the rest of the compounds except THC fall into the ‘‘risk’’ category with MOE , 100. On a population scale, only alcohol would fall into the ‘‘high risk’’ category, and cigarette smoking would fall into the ‘‘risk’’ category, while all other agents (opiates, cocaine, amphetamine-type stimulants, ecstasy, and benzodiazepines) had MOEs . 100, and cannabis had a MOE . 10,000. The toxicological MOE approach validates epidemiological and social science-based drug ranking approach