There are posts about such trips. It is a major undertaking.
The famous Al-Can Highway.
There is no road from U.S. Continent to Alaska - you go thru Canada.
You do need to do lots of preparation for this drive if you are going to do it.
OTOH, driving in Alaska, if you stay on the main areas, i.e. Anchorage to Denali to Fairbank - it is piece of cake. But if you want to venture out to east and other areas - that is a totally different story.