Yes you can

Here is a website with general information about such type of travel.
If you are the right type of person, this may be your dream voyage. Your may even find the mood to write a novel aboard. But it is not for everybody. You cannot get out of the ship if you feel ill or get tired of it. I hope this business sector would grow in the future because it really brings people to experience what it was like a hundred years ago and the navigation discovery era.

http://www.freightercruises.com/