Open letter in support of Chuan-Guo Xiao, M.D. from the
International Academic Community
September 29, 2010
To all,
We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an
internationally respected surgeon-scientist who has made major advances in the
development of neuroregeneration to restore voiding and bowel function. Dr. Xiao
performed groundbreaking animal research in the United States, demonstrating that a
motor nerve that innervates the leg can be used to reinnervate the bladder and
bowel. This reinnervation allows for development of a reflex to initiate bladder
function. The results of his studies were published in peer-reviewed journals and
other scientists have replicated Xiao’s findings confirming these results.
Dr. Xiao eventually took the courageous step of moving from animal research to
human studies and began performing the rerouting procedure on patients with spinal
cord injury and spina bifida in China. Neurogenic bladder is life threatening in China
due to a lack of both antimuscarinics and intermittent catheterization, and lessening
the complications of neurogenic bladder would be considered a lifesaving success.
Patients with neurogenic bladder and bowel suffer greatly and endure a host of issues
such as urinary retention, incontinence, recurrent infections, renal insufficiency,
fecal incontinence, constipation, and poor quality of life. For a procedure as
complicated as nerve rerouting requiring nerve regeneration, one cannot expect
normalization of bladder and bowel function to be the definition of success. What is
important is that the benefits outweigh the risks of the procedure.
Dr. Xiao published his clinical results in peer-reviewed journals and was twice
honored by the Jack Lapides Essay Contest, one of the most respected international
awards given to scientists who make major contributions to the field of neurourology.
In 2008, he was named the Kelm Hjalmas Memorial Lecturer from the International
Children’s Continence Society for his scientific achievements. Many of us have
traveled to China to examine patients treated by Dr. Xiao and/or have been trained
by him in the nerve rerouting surgery he invented. Dr. Xiao is a very skilled surgeon
who is passionate about patient care and works tirelessly to train physicians around
the world in performing his nerve rerouting procedure.
In the United States, an independent and very rigorous pilot research trial was
performed to test the safety and efficacy of this procedure. The one-year results
were recently published in the Journal of Urology. At the 12-month follow-up visit, a
cutaneous to bladder reflex was found in 7 of 9 spina bifida patients, confirming that
rerouting does occur. This finding by itself is remarkable and Dr. Xiao should be
commended. In addition, a number of patients demonstrated improvement in bladder
and bowel function, which has continued to improve with longer patient follow-up.
The 36-month results are currently being analyzed and will be reported in the near
future. The pilot data was supportive of Dr. Xiao’s procedure, and now an NIH
sponsored clinical trial is being conducted to further study lumbar to sacral nerve
rerouting in spina bifida patients. In addition, similar procedures have been done
worldwide, with Dr. Xiao helping to mentor the surgeons at each site.
The Chinese people and government should be proud of Dr. Xiao for his dedication to
his patients, his scientific achievements, and his willingness to train doctors around
the world how to perform his surgery. The International scientific community was
shocked to hear of Dr. Xiao’s arrest. Those of us who know Dr. Xiao well find it
difficult to believe that he is involved in these attacks.
Dr. Xiao is a compassionate man who is respected worldwide for his integrity and his
innovative scientific contributions to society. We implore the Chinese government
and authorities to treat Dr. Xiao fairly and to protect his human rights as these
charges are investigated. Please strongly consider Dr. Xiao’s scientific and
humanitarian contributions to the world as facts are gathered in this case.
Sincerely,
Kenneth M. Peters, MD
Professor and Chairman of Urology
Beaumont Hospital
Royal Oak, Michigan USA
Jack S. Elder, M.D.
Chief of Urology, Henry Ford Health System
Associate Director, Vattikuti Urology Institute
Department of Urology,
Children's Hospital of Michigan
Detroit, MI USA
Edwin A. Smith M.D.
Assistant Clinical Professor of Urology
Emory University School of Medicine
Atlanta, Georgia USA
Kevin M. Feber, MD, FAAP
Beaumont Children's Hospital
Royal Oak, MI USA
Ananias C. Diokno, M.D., F.A.C.S.
Executive Vice President & CMO
Beaumont Hospital
Royal Oak, Michigan 48073 USA
Juan José de Benito
Urologist
Hospital Nacional de Clínicas
Córdoba, Argentina.
William E. Nantau B.Sc., CNIM
Clinical Manager
Clinical Neurophysiology Department
Beaumont Hospital Royal Oak, MI USA
Evan J Kass MD,FACS,FAAP
Chief, Division of Pediatric Urology
Beaumont Childrens Hospital
Professor of Urology, Oakland University-William
Beaumont School of Medicine
USA
Jacques Corcos MD.
Professor of Urology, McGill University
General Secretary of the International Continence
Society
Jewish General hospital
3755 Cote Ste-Catherine
Montreal, Quebec, Canada H3T 1E2
Jose Gonzalez, M.D.
Department of Urology
Beaumont Hospital
Royal Oak, Michigan USA
Christopher Payne, MD
Associate Professor of Urology
Stanford University Medical School
Stanford, CA 94305-5118 USA
Kenneth I. Glas*****erg, MD
Director, Division of Pediatric Urology
Morgan Stanley Children's Hospital of New York-
Pre*****yterian
Professor of Urology, Columbia University
College of Physicians and Surgeons
3959 Broadway, CHN 1118 NY USA
Earl Y. Cheng, MD
Associate Professor of Urology
Children’s Memorial Hospital
Chicago, Illinois USA
Darius J. Bagli, MDCM
Professor of Surgery
Senior Associate Scientist
Director of Urology Research
Divisions of Urology and
Developmental & Stem Cell Biology
The Hospital For Sick Children
Institute of Medical Science
University of Toronto
Henri B. LOTTMANN, MD, FEBU, FEBPS,
FRCS(england) FEBPU
Paediatric urology unit
Hopital Necker-Enfants-Malades
149, rue de Sèvres
75015 Paris, France
Dr. Amrish Vaidya MS. MCh.
Consultant Paediatric Surgeon,
Kokilaben Dhirubhai Ambani Hospital,
4 Bungalows, Andheri W, Mumbai, India
Marc Cendron, MD
Associate Professor in Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA USA
Stuart B. Bauer, MD
Associate Director, Neurourology
Professor of Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA USA
Edmond T. Gonzales, Jr., MD
Professor of Urology
Baylor College of Medicine
Houston TX USA
Richard Macchia, MD FACS
SUNY Distinguished Teaching Professor
Cleveland Clinic, Florida
Benjamin Girdler, MD
Urology Center of the Rockies
Fort Collins, Colorado USA
William C. de Groat, Ph.D.
Professor of Pharmacology
University of Pitt*****urgh
Pitt*****urgh, PA USA
Michael R. Ruggieri, Sr., Ph.D.
Director of Urologic Research
Temple University School of Medicine
Philadelphia, PA USA
Stanley J Kogan MD
Chief, Pediatric Urology
Children's Hospital at Montefiore
Bronx NY USA
Anthony Caldamone, MD
University Urologic Associates, Inc.
2 Dudley St Ste 185
Providence, RI 02905 USA
Yves Homsy MD, FRCSC, FAAP
Clinical Professor of Urological Surgery and
Pediatrics
University of South Florida
Children's Urology Group
5507 E. Longboat Blvd
Tampa FL 33615 USA
Dr. Enrique Turina
Professor of urology of the National University of
Buenos Aires
Chief of section Urology of Instituto de
Rehabilitación
Government of Buenos Aires, Argentina.
Dr. Angel Ozón
Urologist of the Instituto de Rehabilitación of Buenos
Aires
Dr. Daniel Ekizian
Urologist of Instituto de Rehabilitación.
Professor Dr. med. Karl-Dietrich Sievert
Vice Chair
Prof. of Urology, Director - Uro-oncology,
Neurourology, Incontinence, & Reconstructive
Urology
Department of Urology University of Tuebingen
D72076 Tuebingen, Germany
Holly Gilmer, MD
Chief of Pediatric Neurosurgery
Beaumont Hospital
Royal Oak, Michigan USA
Yegappan Lakshmanan, MD
Chief, Pediatric Urology
Children’s Hospital of Michigan
Detroit, MI USA
International Academic Community
September 29, 2010
To all,
We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an
internationally respected surgeon-scientist who has made major advances in the
development of neuroregeneration to restore voiding and bowel function. Dr. Xiao
performed groundbreaking animal research in the United States, demonstrating that a
motor nerve that innervates the leg can be used to reinnervate the bladder and
bowel. This reinnervation allows for development of a reflex to initiate bladder
function. The results of his studies were published in peer-reviewed journals and
other scientists have replicated Xiao’s findings confirming these results.
Dr. Xiao eventually took the courageous step of moving from animal research to
human studies and began performing the rerouting procedure on patients with spinal
cord injury and spina bifida in China. Neurogenic bladder is life threatening in China
due to a lack of both antimuscarinics and intermittent catheterization, and lessening
the complications of neurogenic bladder would be considered a lifesaving success.
Patients with neurogenic bladder and bowel suffer greatly and endure a host of issues
such as urinary retention, incontinence, recurrent infections, renal insufficiency,
fecal incontinence, constipation, and poor quality of life. For a procedure as
complicated as nerve rerouting requiring nerve regeneration, one cannot expect
normalization of bladder and bowel function to be the definition of success. What is
important is that the benefits outweigh the risks of the procedure.
Dr. Xiao published his clinical results in peer-reviewed journals and was twice
honored by the Jack Lapides Essay Contest, one of the most respected international
awards given to scientists who make major contributions to the field of neurourology.
In 2008, he was named the Kelm Hjalmas Memorial Lecturer from the International
Children’s Continence Society for his scientific achievements. Many of us have
traveled to China to examine patients treated by Dr. Xiao and/or have been trained
by him in the nerve rerouting surgery he invented. Dr. Xiao is a very skilled surgeon
who is passionate about patient care and works tirelessly to train physicians around
the world in performing his nerve rerouting procedure.
In the United States, an independent and very rigorous pilot research trial was
performed to test the safety and efficacy of this procedure. The one-year results
were recently published in the Journal of Urology. At the 12-month follow-up visit, a
cutaneous to bladder reflex was found in 7 of 9 spina bifida patients, confirming that
rerouting does occur. This finding by itself is remarkable and Dr. Xiao should be
commended. In addition, a number of patients demonstrated improvement in bladder
and bowel function, which has continued to improve with longer patient follow-up.
The 36-month results are currently being analyzed and will be reported in the near
future. The pilot data was supportive of Dr. Xiao’s procedure, and now an NIH
sponsored clinical trial is being conducted to further study lumbar to sacral nerve
rerouting in spina bifida patients. In addition, similar procedures have been done
worldwide, with Dr. Xiao helping to mentor the surgeons at each site.
The Chinese people and government should be proud of Dr. Xiao for his dedication to
his patients, his scientific achievements, and his willingness to train doctors around
the world how to perform his surgery. The International scientific community was
shocked to hear of Dr. Xiao’s arrest. Those of us who know Dr. Xiao well find it
difficult to believe that he is involved in these attacks.
Dr. Xiao is a compassionate man who is respected worldwide for his integrity and his
innovative scientific contributions to society. We implore the Chinese government
and authorities to treat Dr. Xiao fairly and to protect his human rights as these
charges are investigated. Please strongly consider Dr. Xiao’s scientific and
humanitarian contributions to the world as facts are gathered in this case.
Sincerely,
Kenneth M. Peters, MD
Professor and Chairman of Urology
Beaumont Hospital
Royal Oak, Michigan USA
Jack S. Elder, M.D.
Chief of Urology, Henry Ford Health System
Associate Director, Vattikuti Urology Institute
Department of Urology,
Children's Hospital of Michigan
Detroit, MI USA
Edwin A. Smith M.D.
Assistant Clinical Professor of Urology
Emory University School of Medicine
Atlanta, Georgia USA
Kevin M. Feber, MD, FAAP
Beaumont Children's Hospital
Royal Oak, MI USA
Ananias C. Diokno, M.D., F.A.C.S.
Executive Vice President & CMO
Beaumont Hospital
Royal Oak, Michigan 48073 USA
Juan José de Benito
Urologist
Hospital Nacional de Clínicas
Córdoba, Argentina.
William E. Nantau B.Sc., CNIM
Clinical Manager
Clinical Neurophysiology Department
Beaumont Hospital Royal Oak, MI USA
Evan J Kass MD,FACS,FAAP
Chief, Division of Pediatric Urology
Beaumont Childrens Hospital
Professor of Urology, Oakland University-William
Beaumont School of Medicine
USA
Jacques Corcos MD.
Professor of Urology, McGill University
General Secretary of the International Continence
Society
Jewish General hospital
3755 Cote Ste-Catherine
Montreal, Quebec, Canada H3T 1E2
Jose Gonzalez, M.D.
Department of Urology
Beaumont Hospital
Royal Oak, Michigan USA
Christopher Payne, MD
Associate Professor of Urology
Stanford University Medical School
Stanford, CA 94305-5118 USA
Kenneth I. Glas*****erg, MD
Director, Division of Pediatric Urology
Morgan Stanley Children's Hospital of New York-
Pre*****yterian
Professor of Urology, Columbia University
College of Physicians and Surgeons
3959 Broadway, CHN 1118 NY USA
Earl Y. Cheng, MD
Associate Professor of Urology
Children’s Memorial Hospital
Chicago, Illinois USA
Darius J. Bagli, MDCM
Professor of Surgery
Senior Associate Scientist
Director of Urology Research
Divisions of Urology and
Developmental & Stem Cell Biology
The Hospital For Sick Children
Institute of Medical Science
University of Toronto
Henri B. LOTTMANN, MD, FEBU, FEBPS,
FRCS(england) FEBPU
Paediatric urology unit
Hopital Necker-Enfants-Malades
149, rue de Sèvres
75015 Paris, France
Dr. Amrish Vaidya MS. MCh.
Consultant Paediatric Surgeon,
Kokilaben Dhirubhai Ambani Hospital,
4 Bungalows, Andheri W, Mumbai, India
Marc Cendron, MD
Associate Professor in Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA USA
Stuart B. Bauer, MD
Associate Director, Neurourology
Professor of Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA USA
Edmond T. Gonzales, Jr., MD
Professor of Urology
Baylor College of Medicine
Houston TX USA
Richard Macchia, MD FACS
SUNY Distinguished Teaching Professor
Cleveland Clinic, Florida
Benjamin Girdler, MD
Urology Center of the Rockies
Fort Collins, Colorado USA
William C. de Groat, Ph.D.
Professor of Pharmacology
University of Pitt*****urgh
Pitt*****urgh, PA USA
Michael R. Ruggieri, Sr., Ph.D.
Director of Urologic Research
Temple University School of Medicine
Philadelphia, PA USA
Stanley J Kogan MD
Chief, Pediatric Urology
Children's Hospital at Montefiore
Bronx NY USA
Anthony Caldamone, MD
University Urologic Associates, Inc.
2 Dudley St Ste 185
Providence, RI 02905 USA
Yves Homsy MD, FRCSC, FAAP
Clinical Professor of Urological Surgery and
Pediatrics
University of South Florida
Children's Urology Group
5507 E. Longboat Blvd
Tampa FL 33615 USA
Dr. Enrique Turina
Professor of urology of the National University of
Buenos Aires
Chief of section Urology of Instituto de
Rehabilitación
Government of Buenos Aires, Argentina.
Dr. Angel Ozón
Urologist of the Instituto de Rehabilitación of Buenos
Aires
Dr. Daniel Ekizian
Urologist of Instituto de Rehabilitación.
Professor Dr. med. Karl-Dietrich Sievert
Vice Chair
Prof. of Urology, Director - Uro-oncology,
Neurourology, Incontinence, & Reconstructive
Urology
Department of Urology University of Tuebingen
D72076 Tuebingen, Germany
Holly Gilmer, MD
Chief of Pediatric Neurosurgery
Beaumont Hospital
Royal Oak, Michigan USA
Yegappan Lakshmanan, MD
Chief, Pediatric Urology
Children’s Hospital of Michigan
Detroit, MI USA
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