高风险2型糖尿病人群的药物预防:临床试验成功

来源: 于 2014-03-27 19:01:09 [博客] [旧帖] [给我悄悄话] 本文已被阅读：次

发表在Diabetes Care的一项研究: 对象为前驱期糖尿病(prediabetes)和/或代谢综合征(and/or metabolic syndrome (MetS))人群，BMI在27~25 kg/m2之间。受试者接受为期108周的苯丁胺和托吡酯缓释剂治疗，同时进行生活方式调整。结果显示，这种治疗方案可显著降低体重，并降低发展为2型糖尿病的风险。

CONCLUSIONS  PHEN/TPM ER plus lifestyle modification produced significant weight loss and markedly reduced progression to type 2 diabetes in overweight/obese patients with prediabetes and/or MetS, accompanied by improvements in multiple cardiometabolic disease risk factors.

原文链接:

Prevention of Type 2 Diabetes in Subjects With Prediabetes and Metabolic Syndrome Treated With Phentermine and Topiramate Extended Release

注释:

苯丁胺 = phentermine
托吡酯缓释剂 = topiramate extended release (PHEN/TPM ER)

Fasting Plasma Glucose (FPG) = 空腹血糖
OGTT = oral glucose tolerance test (口服葡萄糖耐量试验)
HbA1c = Hemoglobin A1c (糖化血红蛋白)

 

<span class='tooltip' style='z-index: 1000;'>A1C<span class='definition'>A1C is a test that measures a person's average blood glucose level over the past 2 to 3 months. Hemoglobin (HEE-mo-glo-bin) is the part of a red blood cell that carries oxygen to the cells and sometimes joins with the glucose in the bloodstream. Also called hemoglobin A1C or glycosylated (gly-KOH-sih-lay-ted) hemoglobin, the test shows the amount of glucose that sticks to the red blood cell, which is proportional to the amount of glucose in the blood.<span class='close-tooltip'>X</span></span></span> FPG OGT

 


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