ACE2 表达的含量多少和这个病情严重性不相关

2006 paper

Epidemiologic data suggested that there was an obvious predominance of young adult patients with a slight female proneness in severe acute respiratory syndrome (SARS). The angiotensin-converting enzyme 2 (ACE2) was very recently identified as a functional receptor for SARS virus and is therefore a prime target for pathogenesis and pharmacological intervention. Rats of both genders at three distinct ages (young-adult, 3 months; middle-aged, 12 months; old, 24 months) were evaluated to determine the characteristic of ACE2 expression in lung and the effect of aging and gender on its expression. ACE2 was predominantly expressed in alveolar epithelium, bronchiolar epithelium, endothelium and smooth muscle cells of pulmonary vessels with similar content, whereas no obvious signal was detected in the bronchiolar smooth muscle cells. ACE2 expression is dramatically reduced with aging in both genders: young-adult vs. old P < 0.001 (by 78% in male and 67% in female, respectively) and middle-aged vs. old P < 0.001 (by 71% in male rats and 59% in female rats, respectively). The decrease of ACE2 content was relatively slight between young-adult and middle-aged groups (by 25% in male and 18% in female, respectively). Although there was no gender-related difference of ACE2 in young-adult and middle-aged groups, a significantly higher ACE2 content was detected in old female rats than male. In conclusion, the more elevated ACE2 in young adults as compared to aged groups may contribute to the predominance in SARS attacks in this age group.

 

google translation

流行病学数据表明，在严重急性呼吸综合征（SARS）中，年轻的成年患者具有明显的女性轻度倾向。血管紧张素转换酶2（ACE2）最近被确定为SARS病毒的功能受体，因此是发病机理和药理干预的主要目标。评估了两种性别的大鼠在三个不同的年龄（成人3个月；中年12个月；年龄24个月），以确定ACE2在肺中的表达特征以及衰老和性别对其表达的影响。 ACE2主要在肺泡上皮，细支气管上皮，内皮和肺血管平滑肌细胞中表达，含量相似，而在细支气管平滑肌细胞中未检测到明显的信号。 ACE2的表达随年龄的增长而显着降低：青年与老年P <0.001（男性分别降低78％和女性67％）和中老年与老年P <0.001（男性降低71％）大鼠和59％的雌性大鼠）。 ACE2含量的减少在年轻人和中年组之间相对较小（男性分别降低25％，女性降低18％）。尽管在青年和中年组中没有性别相关的ACE2差异，但在老年雌性大鼠中检出的ACE2含量明显高于雄性。总之，与年龄组相比，年轻人中ACE2的升高可能是该年龄组SARS发作的主要原因。