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VIREAD is indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.

The following points should be considered when initiating therapy with VIREAD for the treatment of HBV infection:

The indication in adults is based on safety and efficacy data from treatment of subjects who were nucleoside-treatment-na?ve and subjects who were treatment-experienced with documented resistance to lamivudine. Subjects were adults with HBeAg-positive and HBeAg-negative chronic hepatitis B with compensated liver disease [See Clinical Studies].
VIREAD was evaluated in a limited number of subjects with chronic hepatitis B and decompensated liver disease [See ADVERSE REACTIONS, Clinical Studies].
The numbers of subjects in clinical trials who had adefovir resistance-associated substitutions at baseline were too small to reach conclusions of efficacy [See Microbiology, Clinical Studies].