NSAID确实能引起肠壁损伤，造成出血甚至形成隔膜。。。

NSAID associated colitis

 

Causes bleeding, diarrhea or abdominal pain

Endoscopy: small erosions in different parts of colon

Treatment: discontinuation of NSAIDs (Z Gastroenterol 2000;38:957)

Micro: usually mixed inflammatory infiltrate, may also be predominantly neutrophilic or lymphocytic; often erosions, crypt architectural disarray; no granulomas

Micro images: ulcer post-NSAID therapy; erosion and neutrophils

DD: Crohn’s colitis, focal active colitis, ischemic colitis

References: AJCP 1998;110:622, Pathologe 2006;27:65, Adv Anat Pathol 1999;6:213