“研究表明免疫记忆至少在 30 年内保持完好”乙肝蛋白疫苗做的非常成功.

https://cont.jd.com/pccontent/1514782

https://www.cdc.gov/hepatitis/hbv/hbvfaq.htm#:~:text=of%20injectable%20vaccines.-,How%20long%20does%20protection%20from%20hepatitis%20B%20vaccine%20last%3F,months%20of%20age%20(21).

How long does protection from hepatitis B vaccine last?

Studies indicate that immunologic memory remains intact for at least 30 years among healthy people who initiated hepatitis B vaccination at >6 months of age (21). The vaccine confers long-term protection against clinical illness and chronic hepatitis B virus infection. Cellular immunity appears to persist even though antibody levels might become low or decline below detectable levels (22). Among vaccinated cohorts who initiated hepatitis B vaccination at birth, long-term follow-up studies are ongoing to determine the duration of vaccine-induced immunity (21).