没法做人的实验。动物实验显示肠道问题先于神经症状出现之前。

“G93A mice have dysbiosis (imbalanced gut bacterial profile), disrupted tight junction structure, and increased intestinal permeability (leaky gut). These changes occur in young G93A mice before ALS symptom onset, suggesting that impaired gut-neuromuscular crosstalk may actively contribute to ALS progression and pathogenesis.”  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344195/?