The genetic diversity of SARSr-CoVs in wildlife and their potential risk of cross-species infection highlights the importance of developing a powerful animal model to evaluate the antibodies and antiviral drugs. We acquired the mouse-adapted strain of a bat-origin coronavirus named SMA1901 by natural serial passaging of rRsSHC014S in BALB/c mice. The SMA1901 infection caused interstitial pneumonia and inflammatory immune responses in both young and aged BALB/c mice after intranasal inoculation. Our model exhibited age-related mortality similar to SARS and COVID-19. Therefore, our model will be of high value for investigating the pathogenesis of bat SARSr-CoVs and could serve as a prospective test platform for prophylactic and therapeutic candidates.
研究病毒是为了对付病毒. 这个视频说了那么多,却只字不提原文白纸黑字写的重要性
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研究病毒也不等于是为了对付病毒,还可以是以防疫为名,实质上是利用病毒制造病毒武器。挂羊头卖狗肉。你完全忽略后一种可能?
-咲媱-
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09/25/2023 postreply
07:18:40
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为什么要到偏远地区的洞穴里采集病毒然后做增益型实验?为啥要增益?有啥好处?出了纰漏,你有能耐管控吗?
-看客2010-
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09/25/2023 postreply
12:36:17
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这在公开的信息里都有,你自己可以找,我不想浪费时间
-SwiperTheFox-
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09/25/2023 postreply
13:14:46
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用得着找嘛,看萨斯2.0就够了。
-看客2010-
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09/25/2023 postreply
13:50:26
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你自己能回答你自己的问题吗? 或者说你已经先入为主地预设了答案, 为什么要来问我?
-SwiperTheFox-
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09/25/2023 postreply
13:53:10
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你问问你自己,你家族中的老人是不是钢筋铁骨百毒不侵特殊材料制成的?是,算额白说;不是,你看着办。
-看客2010-
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09/25/2023 postreply
16:32:36