副总统和超过一半以上的内阁成员提交一封书面报告给参议院的president pro tempore (现任是Chuck Grassley)和众议院的发言人(nancy pelosi), 说总统没有能力行使总统职权, 副总统就可以马上行使代总统职权。
所以,只需要副总统和超过一半以上的内阁成员愿意,25th amendment 就可能成功实施。
Whenever the Vice President and a majority of either the principal officers of the executive departments or of such other body as Congress may by law provide, transmit to the President pro tempore of the Senate and the Speaker of the House of Representatives their written declaration that the President is unable to discharge the powers and duties of his office, the Vice President shall immediately assume the powers and duties of the office as Acting President.