2019-nCoV

Novel coronavirus (2019-nCoV)
Virus classification
(unranked):	Virus
Realm:	Riboviria
Phylum:	incertae sedis
Order:	Nidovirales
Family:	Coronaviridae
Genus:	Betacoronavirus
Subgenus:	incertae sedis
Virus:	Novel coronavirus (2019-nCoV)
Wuhan, China; primary location of the only recorded outbreak
Synonyms
Wuhan seafood market pneumonia virus Wuhan pneumonia Wuhan coronavirus

Genomic information

NCBI genome ID	MN908947
Genome size	30473 bp
Year of completion	2020

 

Novel coronavirus, denoted 2019-nCoV by the WHO^[1][2] and also known as Wuhan coronavirus, Wuhan seafood market pneumonia virus and Wuhan pneumonia,^[3] is a positive-sense, single-stranded RNA coronavirus first reported in 2019. The virus was genomically sequenced after nucleic acid testing on a positive patient sample in a patient with pneumonia during the 2019–2020 Wuhan pneumonia outbreak.^[4][5][6]

In January 2020, human-to-human transmission was confirmed in Guangdong province, China, according to Zhong Nanshan, head of the health commission team investigating the outbreak.^[7] No specific treatment for the new virus is currently available, but existing anti-viralscould be repurposed.^[8]

 

 

Phylogenetics[edit]

Sequences of Wuhan betacoronavirus show similarities to betacoronaviruses found in bats; however, the virus is genetically distinct from other coronaviruses such as Severe acute respiratory syndrome-related coronavirus (SARS) and Middle East respiratory syndrome-related coronavirus (MERS).^[6] Like SARS-CoV, it is a member of Beta-CoV lineage B.^[9]

Five genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the China CDC National Institute for Viral Disease Control and Prevention, Institute of Pathogen Biology, and Wuhan Jinyintan Hospital.^[6][10][11] Its RNA sequence is approximately 30 kbp in length.^[6]

 

References[edit]

1. ^ "Surveillance case definitions for human infection with novel coronavirus (nCoV)". www.who.int. Retrieved 21 January 2020.
2. ^ "Novel coronavirus (2019-nCoV), Wuhan, China". cdc.gov. 10 January 2020. Retrieved 16 January 2020.
3. ^ Zhang, Y.-Z.; et al. (12 January 2020). "Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome". GenBank. Bethesda MD. Retrieved 13 January 2020.
4. ^ "中国疾病预防控制中心". www.chinacdc.cn. Retrieved 9 January 2020.
5. ^ "New-type coronavirus causes pneumonia in Wuhan: expert – Xinhua | English.news.cn". www.xinhuanet.com. Retrieved 9 January 2020.
6. ^ Jump up to:^a b c d "CoV2020". platform.gisaid.org. Retrieved 12 January2020.
7. ^ "China confirms human-to-human transmission of new coronavirus". CBC News. 20 January 2020. Retrieved 21 January 2020.
8. ^ "WHO says new China coronavirus could spread, warns hospitals worldwide". Reuters. 14 January 2020. Retrieved 21 January 2020.
9. ^ "Phylogeny of SARS-like betacoronaviruses". nextstrain. Retrieved 18 January 2020.
10. ^ "Initial genome release of novel coronavirus". Virological. 11 January 2020. Retrieved 12 January 2020.
11. ^ "Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome". 17 January 2020.