Population or subgroup |
BRCA2 mutation(s)[26][29] |
Reference(s) |
Ashkenazi Jewish |
6174delT |
[30] |
Dutch |
5579insA |
[31] |
Finns |
8555T>G, 999del5, IVS23-2A>G |
[32][33] |
French Canadians |
8765delAG, 3398delAAAAG |
[34][35][36] |
Hungarians |
9326insA |
[37] |
Icelandics |
999del5 |
[27][28] |
Italians |
8765delAG |
[38] |
Northern Irish |
6503delTT |
[39] |
Pakistanis |
3337C>T |
[40] |
Scottish |
6503delTT |
[39] |
Slovenians |
IVS16-2A>G |
[41] |
Spanish |
3034delAAAC(codon936), 9254del5 |
[42] |
Swedish |
4486delG |
[43] |
上面为目前报道过的与乳腺癌有关的BRCA2 的变异。
如果没有基因突变一般不要双侧乳房切除。基因检测结果对目前化疗方案没有影响。