各国的癌症冠军:中美英日澳什么癌症(与其他国家相比)发病率最高?

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Population-Based Studies

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One way of identifying the various causes of cancer is by studying populations and behaviors. This approach compares cancer rates among various groups of people exposed to different factors or exhibiting different behaviors. A striking finding to emerge from population studies is that cancers arise with different frequencies in different areas of the world. For example, stomach cancer is especially frequent in Japan, colon cancer is prominent in the United States, and skin cancer is common in Australia. What is the reason for the high rates of specific kinds of cancer in certain countries?

Population-Based Studies

 

Table 23-1Variation Between Countries in the Incidence of Some Common Cancers

SITE OF ORIGIN OF CANCER HIGH-INCIDENCE POPULATION LOW-INCIDENCE POPULATION
  LOCATION INCIDENCE* LOCATION INCIDENCE*
Lung USA (New Orleans, blacks) 110 India (Madras) 5.8
Breast Hawaii (Hawaiians) 94 Israel (non-Jews) 14.0
Prostate USA (Atlanta, blacks) 91 China (Tianjin) 1.3
Uterine cervix Brazil (Recife) 83 Israel (non-Jews) 3.0
Stomach Japan (Nagasaki) 82 Kuwait (Kuwaitis) 3.7
Liver China (Shanghai) 34 Canada (Nova Scotia) 0.7
Colon USA (Connecticut, whites) 34 India (Madras) 1.8
Melanoma Australia (Queensland) 31 Japan (Osaka) 0.2
Nasopharynx Hong Kong 30 UK (Southwestern) 0.3
Esophagus France (Calvados) 30 Romania (urban Cluj) 1.1
Bladder Switzerland (Basal) 28 India (Nagpur) 1.7
Uterus USA (San Francisco Bay Area, whites) 26 India (Nagpur) 1.2
Ovary New Zealand (Polynesian Islanders) 26 Kuwait (Kuwaitis) 3.3
Rectum Israel (European and USA born) 23 Kuwait (Kuwaitis) 3.0
Larynx Brazil (São Paulo) 18 Japan (rural Miyagi) 2.1
Pancreas USA (Los Angeles, Koreans) 16 India (Poona) 1.5
Lip Canada (Newfoundland) 15 Japan (Osaka) 0.1
Kidney Canada (NWT and Yukon) 15 India (Poona) 0.7
Oral cavity France (Bas-Rhin) 14 India (Poona) 0.4
Leukemia Canada (Ontario) 12 India (Nagpur) 2.2
Testis Switzerland (urban Vaud) 10 China (Tianjin) 0.6
*

Incidence = number of new cases per year per 100,000 population, adjusted for standardized population age distribution (so as to eliminate effects due merely to differences of population age distribution). Figures for cancers of breast, uterine cervix, uterus, and ovary are for women; other figures are for men. (Adapted from V.T. DeVita, S. Hellman, and S.A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, 4th edn. Philadelphia: Lippincott, 1993; based on data from C. Muir et al., Cancer Incidence in Five Continents, Vol. 5. Lyon: International Agency for Research on Cancer, 1987.)

From: 

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.