【Type 2 diabetes - pattern of inheritanc】

Type 2 diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The risk of developing type 2 diabetes increases with the number of affected family members. The increased risk is likely due in part to shared genetic factors, but it is also related to lifestyle influences (such as eating and exercise habits) that are shared by members of a family.

https://ghr.nlm.nih.gov/condition/type-2-diabetes#inheritance

Most cases of diabetes mellitus type 2 involved many genes contributing small amount to the overall condition.^[1] As of 2011 more than 36 genes have been found that contribute to the risk of type 2 diabetes.^[2] All of these genes together still only account for 10% of the total genetic component of the disease.^[2]

There are a number of rare cases of diabetes that arise due to an abnormality in a single gene (known as monogenic forms of diabetes).^[1] These include maturity onset diabetes of the young (MODY), Donohue syndrome, and Rabson–Mendenhall syndrome, among others.^[1] Maturity onset diabetes of the young constitute 1–5% of all cases of diabetes in young people.^[3]

 

Genetic cause and mechanism of type 2 diabetes is largely unknown. However, single nucleotide polymorphism (SNP) is one of many mechanisms that leads to increased risk for type 2 diabetes.

https://en.wikipedia.org/wiki/Genetic_causes_of_diabetes_mellitus_type_2?

 

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1: RNA Polymerase, 2: Repressor, 3: Promoter, 4: Operator, 5: Lactose, 6: lacZ, 7: lacY, 8: lacA.

 

p r o m o t o r 

repressor / depressor

operator

triger

initiator