这考医学院的物理题,我看了头都炸了

来源: 2020-12-21 01:13:07 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读: 次 (8321 bytes)
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娃回家准备开始复习MCAT,拿半套diagnostic exam测试一下

物理我懂的,拿他一道题看看,头一下就炸了。这是物理吗?common core害死猫 急

Passage 1 (Questions 1 - 5)

Oral drug delivery systems are limited by the short gastrointestinal transit time, leading to low bioavailability. Drug delivery systems able to retain the dosage form in the stomach are needed. Research into floating drug delivery systems (FDDS) may satisfy this need.

FDDS can be approached by either effervescent or non-effervescent techniques. Ideal effervescent techniques achieve floating duration times > 16 hours in the stomach. Effervescent FDDS incorporate gas-generating agents, which provide buoyancy. Newer research focuses on non-effervescent systems, where the swelling of polymers joined to the drug entraps air within the polymeric matrix, providing buoyancy to the dosage form.

A study was performed on the antidiabetic sulfonylurea glipizide. The drug and one of three polymers were mixed in a mortar according to the ratios described in Table 1. A drop of water was added, and the mixture was kneaded until a homogenous paste was obtained. The mixture was then placed in an oven at 50°C for 30 min to remove water. The compound was then compressed into tablets which served as the basis for drug release and buoyancy measurements.

Table 1 The density of glipizide and the three polymers and the drug to polymer ratio in each trial

To test in vitro drug release of solid dispersions, the tablets were placed into dissolution vessels containing 900 mL of 0.1 M HCl. Dissolution studies were carried out for one hour, with samples withdrawn at predetermined intervals. Drug concentrations were assayed using HPLC methods. The dissolution experiments were carried out in triplicate, and the results are shown in Figure 1. In vitro buoyancy was also tested. Tablets were placed in a vessel containing 500 mL of 0.1 M HCl. The time taken for the tablet to rise to the surface of the dissolution media (floating lag time) and total duration that the tablet remained on the surface (total floating time) were recorded.

Figure 1 Drug release as a function of time and pill composition 

The Ksp for glipizide-cyclodextrin in a chyme solution at 37ºC was determined to be 5.8 x 10-4. Increased solubility of drug dispersions may be achieved by wetting via hydrophilic polymers, or by polymer size reduction.

(Note: all pills for the above trials have the same volume.)

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你这神编辑搞的,无法作答啊 -聪明老爹- 给 聪明老爹 发送悄悄话 聪明老爹 的个人群组 (177 bytes) () 12/21/2020 postreply 06:01:45

老兄啊, B 对是没错的。你一算比重, 方向就大错特错了。 这不是测浮力, 这是测 FloatingLagTime 。。。 -古道阳关- 给 古道阳关 发送悄悄话 古道阳关 的博客首页 古道阳关 的个人群组 (53 bytes) () 12/21/2020 postreply 06:26:22

选项只有ABCD四个。闭着眼睛也是25%正确率吧?但是只有22%的学生做对了? -greenoasis- 给 greenoasis 发送悄悄话 greenoasis 的个人群组 (98 bytes) () 12/21/2020 postreply 08:04:32

这题太烧脑, -千里一盏灯- 给 千里一盏灯 发送悄悄话 千里一盏灯 的博客首页 千里一盏灯 的个人群组 (278 bytes) () 12/21/2020 postreply 08:44:40

每道题1分钟 -wzg69- 给 wzg69 发送悄悄话 wzg69 的博客首页 wzg69 的个人群组 (51 bytes) () 12/21/2020 postreply 11:30:46

这种题上大学物理课也学不到吧。你说可以融会贯通那当然应该。但是是不是说,考MCAT得单独去学这路子的内容? -greenoasis- 给 greenoasis 发送悄悄话 greenoasis 的个人群组 (0 bytes) () 12/21/2020 postreply 08:39:40

我也没搞懂 -wzg69- 给 wzg69 发送悄悄话 wzg69 的博客首页 wzg69 的个人群组 (59 bytes) () 12/21/2020 postreply 09:32:17

大学好像学过医学物理学,都是和医学有关的物理知识 -飞黎- 给 飞黎 发送悄悄话 飞黎 的个人群组 (0 bytes) () 12/21/2020 postreply 13:03:59

Question 4 -wzg69- 给 wzg69 发送悄悄话 wzg69 的博客首页 wzg69 的个人群组 (2551 bytes) () 12/21/2020 postreply 09:30:29

公式在C里给了,不用背啊。又,第一题的正确答案是什么,从你贴的好像是C,但大家都说是B? -N.- 给 N. 发送悄悄话 N. 的博客首页 N. 的个人群组 (0 bytes) () 12/21/2020 postreply 09:42:35

第一题答案C,第4题答案C -wzg69- 给 wzg69 发送悄悄话 wzg69 的博客首页 wzg69 的个人群组 (111 bytes) () 12/21/2020 postreply 09:48:53

Wow! 怪不得医生不好考。学音乐的本科,还得再学其它的才能考MCAT吧? -N.- 给 N. 发送悄悄话 N. 的博客首页 N. 的个人群组 (0 bytes) () 12/21/2020 postreply 09:53:07

我也怀疑。学音乐的本科,再加个物理? -wzg69- 给 wzg69 发送悄悄话 wzg69 的博客首页 wzg69 的个人群组 (20 bytes) () 12/21/2020 postreply 10:49:05

有大纲?里面有要求记的公式吗? -greenoasis- 给 greenoasis 发送悄悄话 greenoasis 的个人群组 (0 bytes) () 12/21/2020 postreply 10:04:40

还不知道 -wzg69- 给 wzg69 发送悄悄话 wzg69 的博客首页 wzg69 的个人群组 (0 bytes) () 12/21/2020 postreply 10:07:57

Can you copy/past the question here? Those Q banks generally ha -4657238- 给 4657238 发送悄悄话 4657238 的个人群组 (0 bytes) () 01/03/2021 postreply 04:46:17

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