伦敦大学: 体内寄生虫产生的衍生物帮助人对抗衰老 zt

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伦敦大学学院的一项新研究显示,寄生虫可能是“青春之泉”药丸的关键。

研究人员认为,被钩虫和鞭虫等寄生蠕虫衍生的蛋白质感染,可以预防心脏病,痴呆症和其他威胁生命的疾病。

它可以帮助抵抗炎症和抵御与年龄有关的疾病。

这些蠕虫曾经在我们的肠道中无害生活,但由于我们的现代生活方式,包括良好的卫生条件,这些蠕虫已从西方人中消失了。

但是主要作者布鲁斯·张(Bruce Zhang)是伦敦大学学院健康老化研究所的生物学专业学生,他说,失去“老朋友”可能与衰老相关的炎症增加有关。

他说:“发达国家对共生微生物和肠道蠕虫的接触减少与过敏性和自身免疫性炎症性疾病的患病率增加有关。”

“另一种可能性是这种'老朋友'微生物和蠕虫的损失增加了无菌的,与衰老相关的炎症,称为炎症。”

这项研究是对先前发表在eLife上的研究的评估,它增加了蠕虫疗法可以帮助我们保持年轻的可能性。

研究人员说,以前的研究表明,炎症加剧了一系列疾病,包括癌症,慢性阻塞性肺疾病和骨质疏松症。

一种理论认为它是由肠道微生物组的变化引起的,但很少有人考虑宏生物组的作用-大于细菌的生物的生态系统。

这包括蠕虫,例如吸虫,tape虫和线虫。回顾以前的论文发现,蠕虫疗法可以成功治疗炎症性疾病,如乳糜泻。研究表明,它也可以阻止甚至逆转衰老过程。

研究人员说,蠕虫的丢失与哮喘,湿疹,肠病,多发性硬化症,类风湿性关节炎和糖尿病有关。一些研究表明,感染蠕虫可以缓解症状,动物实验表明,它们还可以降低患病的风险。

研究人员说,这表明使用蠕虫来源的蛋白质可能会获得相同的益处,并且是一种更安全,更可口的选择。

该研究的合著者,UCL的David Gems教授补充说:“毋庸置疑,改善卫生状况和消除蠕虫寄生虫对人类具有不可估量的好处。

“但是与这种好处相关的成本是免疫功能异常。

“在上个世纪成功消除蠕虫病之后,现在似乎是时候进一步探索它们可能带来的好处了,特别是对于我们的老龄人口而言-这听起来很奇怪。”

其他研究表明,蠕虫来源的蛋白质可以使暴露于垃圾食品的小鼠体内的肠道细菌增强。

它还减少了脂肪组织,脂肪组织被认为是发炎的主要来源。

有趣的是,在常见的蠕虫感染地区,已发现与炎症相关疾病的发生率较低。

例如在印度东部,已发现该蠕虫可预防类风湿关节炎。流行病学研究还显示,蠕虫可预防2型糖尿病和动脉阻塞。

作者在总结性研究论文中说:“现有证据表明,蠕虫恢复性疗法不仅在一定程度上有效应对变态反应和自身免疫性炎症性疾病,而且还可以预防与年龄相关的炎症。

“如果能够证实这一点,蠕虫疗法可以为炎症引起的各种与年龄有关的疾病提供保护。”

 

Parasitic worms could hold the key to a 'fountain of youth' pill, according to new research from University College London.

Being infected with proteins derived from parasitic helminths, like hookworms and whipworms, may prevent heart disease, dementia and other life threatening conditions, researchers suggest.

And it could help fight inflammation and ward off age related illnesses.

The worms, which once lived harmlessly in our intestines, have largely disappeared from westerners due to our modern lifestyles, including good sanitation.

But lead author Bruce Zhang, a biology student at University College London's Institute of Healthy Ageing, said the loss of our “old friends” may be linked to increases in ageing-associated inflammation.

"A decline in exposure to commensal microbes and gut helminths in developed countries has been linked to increased prevalence of allergic and autoimmune inflammatory disorders,” he said.

"A further possibility is this loss of 'old friend' microbes and helminths increases the sterile, ageing-associated inflammation known as inflammageing."

The study, an assessment of previous research into the topic, published in eLife, raises the possibility that helminth therapy could help keep us young.

Previous research suggests that inflammageing fuels a range of disorders from cancer, chronic obstructive pulmonary disease, and osteoporosis, the researchers said.

One theory is that it is caused by changes in the gut microbiome, but little consideration has been given to the role of the macrobiome - the ecosystem of organisms larger than bacteria.

This includes helminths such as flukes, tapeworms and nematodes. A review of previous papers found helminth therapy can successfully treat inflammatory disorders such as coeliac disease. It can also stop - or even reverse - the ageing process, research has suggested.

The loss of helminths has been linked to asthma, eczema, bowel disease, multiple sclerosis, rheumatoid arthritis and diabetes, the researchers said. Some studies have shown infection with helminths soothes symptoms and animal experiments suggest they also reduce the risk of disease.

This indicates using helminth-derived proteins may achieve the same benefits and would be a safer and more palatable option, the researchers said.

Study co-author Prof David Gems, of UCL, added: "It goes without saying improvements in hygiene and elimination of helminth parasites have been of incalculable benefit to humanity.

"But a cost coupled to this benefit is abnormalities of immune function.

"In the wake of successes during the last century in eliminating the evil of helminths, the time now seems right to further explore their possible benefits, particularly for our ageing population - strange as this may sound."

Other research has shown helminth-derived proteins can boost good gut bacteria in mice exposed to a junk food diet.

It also reduced fat tissue, which is known to be a major source of inflammageing.

Interestingly, lower rates of inflammageing-related disease have been identified in areas where helminth infection is common.

For instance in Eastern India, the worms have been found to prevent rheumatoid arthritis. Epidemiological studies have also shown helminths protect against type 2 diabetes and blocked arteries.

Concluding their exploratory paper, the authors said: “Available evidence suggests that restorative helminth therapies are effective against not only allergic and autoimmune inflammatory disorders, but also age-associated inflammation in later life, at least to some extent.

“Should this be confirmed, helminth therapy could provide protection against the wide spectrum of age-related diseases promoted by inflammageing.”

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that is something called "dirty make you healthy" -fuz- 给 fuz 发送悄悄话 fuz 的博客首页 fuz 的个人群组 (0 bytes) () 02/14/2021 postreply 15:15:22

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