一篇在Circulation发表的新论文:基于PULS心脏测试,mRNA新冠疫苗明显增加内皮炎症标志物和ACS风险

来源: 2021-11-25 06:21:52 [] [旧帖] [给我悄悄话] 本文已被阅读: 次 (7686 bytes)
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https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.10712

Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning

Originally publishedCirculation. 2021;144:A10712

Our group has been using the PLUS Cardiac Test (GD Biosciences, Inc, Irvine, CA) a clinically validated measurement of multiple protein biomarkers which generates a score predicting the 5 yr risk (percentage chance) of a new Acute Coronary Syndrome (ACS). The score is based on changes from the norm of multiple protein biomarkers including IL-16, a proinflammatory cytokine, soluble Fas, an inducer of apoptosis, and Hepatocyte Growth Factor (HGF)which serves as a marker for chemotaxis of T-cells into epithelium and cardiac tissue, among other markers. Elevation above the norm increases the PULS score, while decreases below the norm lowers the PULS score.The score has been measured every 3-6 months in our patient population for 8 years. Recently, with the advent of the mRNA COVID 19 vaccines (vac) by Moderna and Pfizer, dramatic changes in the PULS score became apparent in most patients.This report summarizes those results. A total of 566 pts, aged 28 to 97, M:F ratio 1:1 seen in a preventive cardiology practice had a new PULS test drawn from 2 to 10 weeks following the 2nd COVID shot and was compared to the previous PULS score drawn 3 to 5 months previously pre- shot. Baseline IL-16 increased from 35=/-20 above the norm to 82 =/- 75 above the norm post-vac; sFas increased from 22+/- 15 above the norm to 46=/-24 above the norm post-vac; HGF increased from 42+/-12 above the norm to 86+/-31 above the norm post-vac. These changes resulted in an increase of the PULS score from 11% 5 yr ACS risk to 25% 5 yr ACS risk. At the time of this report, these changes persist for at least 2.5 months post second dose of vac.We conclude that the mRNA vacs dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.

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值得关注,虽然有expressions of concern 字样 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 dudaan 的个人群组 (96 bytes) () 11/25/2021 postreply 06:33:26

谢谢,改了。 -万里送行舟- 给 万里送行舟 发送悄悄话 万里送行舟 的个人群组 (0 bytes) () 11/25/2021 postreply 06:47:07

1. 这个观察值得重复验证。2. 这只是个摘要,不是完整论文。3. 只有一位作者 -吃与活- 给 吃与活 发送悄悄话 吃与活 的博客首页 吃与活 的个人群组 (134 bytes) () 11/25/2021 postreply 11:36:37

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