Junying Yuan received her Ph.D. in Neuroscience from Harvard University in 1989 and her undergraduate degree from Fudan University, Shanghai, China, in 1982. Dr. Yuan carried out her Ph.D thesis work at the Massachusetts Institute of Technology. She was first appointed as Assistant Professor at Harvard Medical School in 1992, when she became a Principal Investigator of the Cardiovascular Research Center at Massachusetts General Hospital. She joined the Department of Cell Biology in 1996 and was appointed a Professor of Cell Biology at Harvard Medical School in 2000.
Junying Yuan is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School, best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis.Wikipedia
Junying Yuan (Chinese: 袁钧瑛; pinyin: Yuán Jūnyīng, born October 3, 1958) is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School,[1] best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis.[2][3] More recently, she was responsible for the discovery of the programmed form of necrotic cell death known as necroptosis.[4]
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In the United States, she completed her PhD in Neuroscience(1989) at Harvard University under the supervision of MIT professor H. Robert Horvitz, where she endeavored to elucidate the molecular mechanisms behind programmed cell death in the nematodeCaenorhabditis elegans. She identified the proteins ced-3 and ced-4 as drivers behind programmed cell death in C. elegans, and subsequently identified the mammalian homologue of ced-3 known as interleukin-1 beta-converting enzyme(ICE), later called caspase-1.[2][3][7]
Junying Yuan established an independent lab at Harvard-affiliated Massachusetts General Hospital in 1989, immediately upon completion of her PhD.[6] Her initial efforts were directed towards providing evidence for the functional role of caspases in mediating mammalianapoptosis.[8][9] Her independent work at this stage provided the first insights into molecular mechanisms in mammalian apoptosis, which contributed significantly to the Nobel Prize in Chemistry won by her PhD supervisor, Robert Horvitz.[10]
In 1996, Yuan moved her lab to the Department of Cell Biology at Harvard Medical School's Longwood campus, where she continued her investigation into cell death. Her work delved further into programmed cell death and revealed a wide cohort of proteins involved in the regulation and consequences of apoptosis. Some notable work includes her discovery that BID cleavage by caspase-8 mediates mitochondrial damage in apoptosis,[11] and her discovery of caspase-11's role in regulating caspase-1-driven inflammation.[12]
In 2005, Yuan's group discovered a non-apoptotic form of programmed necrotic cell death, which they termed "necroptosis".[4] Other groups first observed that the stimulation of Fas/TNFR family of death-domain receptors(DR) activated a canonical apoptotic pathway; however, in many cell types, not only did caspase inhibition fail to inhibit cell death, as would be expected of canonical apoptosis, but stimulated cells experienced a form of cell death that more closely resembled necrosis than apoptosis.[13] Yuan's group conducted a chemical screen that identified a small molecule capable of inhibiting DR-driven cell death, necrostatin-1, and demonstrated necroptosis' role in ischemic neuronal injury, thereby positing a potential role for necrostatin-1 in stroke treatment. Her group then identified RIPK1 as the target for necrostatin-1,[14] thus implicating it as a key player in necroptosis. Yuan went on to identify and characterize members of the signaling network responsible for regulating necroptosis,[15] and continues to elucidate the mechanisms of necroptosis while exploring its potential as a target of therapeutic intervention. Necrosis was previously considered to be a form of passive cell death, forced in response to stress. This belief had driven an aversion towards developing therapeutic applications targeting necrosis. In demonstrating a form of programmed necrosis, Yuan's work revealed new avenues of treatment for an ever-increasing cohort of diseases where necroptosis is implicated.[16]
^ Jump up to: abYuan, J. Y.; Horvitz, H. R. (1990). "The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death". Developmental Biology. 138 (1): 33–41. doi:10.1016/0012-1606(90)90174-h. PMID2307287.
^ Jump up to: abYuan, J; Horvitz, H. R. (1992). "The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death". Development (Cambridge, England). 116 (2): 309–20. PMID1286611.
^ Jump up to: abDegterev, A; Huang, Z; Boyce, M; Li, Y; Jagtap, P; Mizushima, N; Cuny, G. D.; Mitchison, T. J.; Moskowitz, M. A.; Yuan, J (2005). "Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury". Nature Chemical Biology. 1 (2): 112–9. doi:10.1038/nchembio711. PMID16408008.
Jump up ^Yuan, J; Shaham, S; Ledoux, S; Ellis, H. M.; Horvitz, H. R. (1993). "The C. Elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme". Cell. 75 (4): 641–52. doi:10.1016/0092-8674(93)90485-9. PMID8242740.
Jump up ^Miura, M; Zhu, H; Rotello, R; Hartwieg, E. A.; Yuan, J (1993). "Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. Elegans cell death gene ced-3". Cell. 75 (4): 653–60. doi:10.1016/0092-8674(93)90486-a. PMID8242741.
Jump up ^Gagliardini, V; Fernandez, P. A.; Lee, R. K.; Drexler, H. C.; Rotello, R. J.; Fishman, M. C.; Yuan, J (1994). "Prevention of vertebrate neuronal death by the crmA gene". Science. 263 (5148): 826–8. doi:10.1126/science.8303301. PMID8303301.
Jump up ^Li, H; Zhu, H; Xu, C. J.; Yuan, J (1998). "Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis". Cell. 94 (4): 491–501. doi:10.1016/s0092-8674(00)81590-1. PMID9727492.
Jump up ^Degterev, A; Hitomi, J; Germscheid, M; Ch'En, I. L.; Korkina, O; Teng, X; Abbott, D; Cuny, G. D.; Yuan, C; Wagner, G; Hedrick, S. M.; Gerber, S. A.; Lugovskoy, A; Yuan, J (2008). "Identification of RIP1 kinase as a specific cellular target of necrostatins". Nature Chemical Biology. 4 (5): 313–21. doi:10.1038/nchembio.83. PMID18408713.
the answer is "yes" - full professor with tenure. I worked in the Departmental Chair's lab, adjacent to Yuan's lab at Harvard. A major part of Horvitz's Nobel Prize work was done by Yuan, a giant in cell biology. She's member of American Academy of Arts and Science, Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School. Her English is superb! She chairs a lot of NIH Study Sections (grants) and symposiums nationwide. Harvard Cell Biology Department has 15 members of the National Academy of Sciences, USA - it's extremely competitive to get into the Faculty - it's cutting-throat to stay on the faculty, which tells a lot about Yuan work. Check the list for fellow Chinese faculty online (It used to have Rong Li, a girl professor).
junying yuan harvard
Junying Yuan
Junying Yuan is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School, best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis. Wikipedia
Born: October 3, 1958 (age 58), Shanghai, China
Field: Biology
Institution: Harvard Medical School
Alma maters: Fudan University, Harvard University, Massachusetts Institute of Technology
Academic advisor: H. Robert Horvitz http://cellbio.med.harvard.edu/people/faculty/yuan
tenured professor 翻译成 终生教授 及 Fellow 翻译成 院士: 这是错误!
A Tenured Professor (1990) is a satirical novel by Canadian/American economist and Professor Emeritus at Harvard, John Kenneth Galbraith, about a liberal university teacher who sets out to change American society by making money and then using it for the public good. Set at Harvard mainly during the Reagan administration, the plot and all the characters that appear in the story are entirely fictitious. 一个自由的大学老师开始赚钱美国社会的变革,然后用它为公益. 通俗翻译就是一个上了轨道的专业人。
The book chronicles the rise to fame of one Montgomery Marvin, a professor of economics who, as an academic teacher, keeps a low profile but who nevertheless is given tenure quite early in his career. While outwardly concerning himself with unspectacular research focusing on "Mathematical Paradigms in an Approach to Refrigerator Pricing" (which is also the title of his Ph.D. thesis), Marvin's extracurricular activities centre on becoming very rich in a very short time. For that purpose, Marvin has devised a new formula—a stock forecasting model by means of which he and his wife can cash in on people's euphoria, greed and, as they call it, dementia. Eventually, while everyone loses money in the wake of the "Black Monday" stock market crash of October 19, 1987, the Marvins gain an awful lot. (See also Michael Milken and leveraged buyout.)
They decide to spend their money wisely, according to their liberal agenda. Intent on strictly observing the code of business ethics, they start to make use of the "positive power of wealth" and embark on a life of philanthropy. They fund a number of chairs in peace studies to be established at, of all places, military academies. They also secure legislation by which companies are required to label their products according to the percentage of female executives employed by them. After they have launched several of their projects, their operations are increasingly considered un-American and officially put under surveillance. But whatever will happen - Marvin knows that he will be able to nourish his family, as he has been accorded tenure.
A Tenured Professor was republished as paperback by Houghton Mifflin in 2001 (ISBN 0-618-15455-8).
In academia, a fellow (学有专长的会士或同仁) is a member of a group of learned people who work together as peers in the pursuit of mutual knowledge or practice. Fellows may include visiting professors, postdoctoral researchers and doctoral researchers. It may also indicate an individual recipient of a graduate-level merit-based form of funding akin to a scholarship.
Interdisciplinary Research Center on Biology and Chemistry 这个翻译:Interdisciplinary Research Center focused on Biology and Chemistry
博主回复(2016-12-7 14:52):正确:Interdisciplinary Research Center for Biology and Chemistry 这个翻译:Interdisciplinary Research Center focused on Biology and Chemistry。 “for” is better than "of", but not "on". if the latter is used In Chilish