癌症福音：纳米金颗粒可以选择性地进攻癌细胞

Gold makes for an effective anti-cancer bomb, says study

Unlike chemotherapy, drugs attached to gold nanoparticles target only cancerous cells, find scientists

 

ANI

Posted On Sunday, February 06, 2011 at 06:16:39 AM

Gold nanoparticles stick to cancer cells and make them shine Scientists have found that gold nanoparticles can achieve something for cancer patients that chemotherapy cannot — killing the cancer cells without harming the healthy ones. Preliminary tests have shown that an anti-cancer drug loosely attached to gold nanoparticles starts accumulating deep inside tumors within minutes of injection and can be activated for an effective treatment within two hours. The same drug injected alone takes two days to gather and attacks the tumor from the surface — a far less effective route. Speeding anti-cancer drugs directly into tumors enables patients to receive lower doses of the toxic chemicals, thereby saving healthy tissue from damage and other harsh side effects suffered in traditional chemotherapy. “We hope to lower the dosage by at least a factor of 10,” said Clemens Burda, a professor of chemistry at Case Western Reserve University and senior author of the paper. The scientists tied an anti-cancer drug to golden missiles using a weak chemical interaction called a noncovalent bond. They found that by using a noncovalent bond to attach the drug to coated gold, they eliminated interference among the desired properties of each component. The coated gold provides an environment to physically prevent activation of the photodynamic therapy drug silicon phthalocyanine, preventing unintended toxic exposures to healthy tissues. The loosely-held drug is released from the nanoparticle through the attraction of the drug to the lipid membrane of cancer cells. Laser light switches on the freed silicon phthalocyanine, which breaks down and kills cancer cells, shrinking the tumor. After delivering the drug, the nanoparticles pass through the kidneys and clear the body within a week. The findings have been published in the Journal of the American Chemical Society.

所有跟帖： 

• 回复： -viewfinder- ♀ (362 bytes) () 02/06/2011 postreply 08:10:53

• 这方面的研究很多，例临床应用还早。 -Stonypoint- ♂ (580 bytes) () 02/06/2011 postreply 15:51:00

• 是啊，次次都有激动人心的突破，次次都不了了之，雷声大，雨点小 -医者意也- ♂ (0 bytes) () 02/07/2011 postreply 10:44:20