胆固醇看来的确是被冤枉了

根据 Sachdeva et al 在 Am Heart J (157:111-117, 2009)杂志的报导， 近50%的心血管病人的LDL-胆固醇是正常的。这就说明胆固醇不可能是心血管病的病因。否则大多数病人的胆固醇应该是高于正常值。

 

另外一个报导 （Cardiol J, 16:227-233, 2009)显示，LDL-胆固醇正常的心脏病病人 （LDL-C ＜or =105 mg /dL）3年的死亡率高于LDL-C ＞105mg /dL的心脏病病人 （14.8% vs 7.1%)。这个报导表明胆固醇低可能不利于健康。

 

Lancet. 2001 Aug 4;358(9279):351-5.

Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study.

Schatz IJ, Masaki K, Yano K, Chen R, Rodriguez BL, Curb JD.

Source

Clinical Epidemiology and Geriatrics Division, Department of Medicine, John A Bums School of Medicine, University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813-2427, USA. [e-mail]

Abstract

BACKGROUND:

A generally held belief is that cholesterol concentrations should be kept low to lessen the risk of cardiovascular disease. However, studies of the relation between serum cholesterol and all-cause mortality in elderly people have shown contrasting results. To investigate these discrepancies, we did a longitudinal assessment of changes in both lipid and serum cholesterol concentrations over 20 years, and compared them with mortality.

METHODS:

Lipid and serum cholesterol concentrations were measured in 3572 Japanese/American men (aged 71-93 years) as part of the Honolulu Heart Program. We compared changes in these concentrations over 20 years with all-cause mortality using three different Cox proportional hazards models.

FINDINGS:

Mean cholesterol fell significantly with increasing age. Age-adjusted mortality rates were 68.3, 48.9, 41.1, and 43.3 for the first to fourth quartiles of cholesterol concentrations, respectively. Relative risks for mortality were 0.72 (95% CI 0.60-0.87), 0.60 (0.49-0.74), and 0.65 (0.53-0.80), in the second, third, and fourth quartiles, respectively, with quartile 1 as reference. A Cox proportional hazard model assessed changes in cholesterol concentrations between examinations three and four. Only the group with low cholesterol concentration at both examinations had a significant association with mortality (risk ratio 1.64, 95% CI 1.13-2.36).

INTERPRETATION:

We have been unable to explain our results. These data cast doubt on the scientific justification for lowering cholesterol to very low concentrations (<4.65 mmol/L) in elderly people.

 

 

 

 

所有跟帖： 

• 人离了胆固醇不可能存活，LDL, HDL, TDL,TGC,,,,, -弓尒- ♂ (0 bytes) () 05/22/2013 postreply 21:00:56

• 没错，足够的胆固醇对健康很重要，人为的降低可能有害。。 -ERommel- ♂ (0 bytes) () 05/22/2013 postreply 21:09:22

• 不能多， 也不能木有~：） -弓尒- ♂ (0 bytes) () 05/23/2013 postreply 09:56:32

• 关键的问题是，多高算太多，按目前标准，正常值很可能算过低了：） -ERommel- ♂ (0 bytes) () 05/23/2013 postreply 17:41:29

• 啊，又被误导了？ -husky- ♂ (0 bytes) () 05/22/2013 postreply 23:31:56

• 不少报导显示致少现在定的正常值是误导 -ERommel- ♂ (0 bytes) () 05/23/2013 postreply 17:43:38

• 看来医生都把我们给忽悠了。 -大臭臭- ♀ (0 bytes) () 05/23/2013 postreply 08:30:16

• 其实很多医生完全是按专家制定的标准办事，自己不搞研究是发现不了问题的 -ERommel- ♂ (0 bytes) () 05/23/2013 postreply 17:45:30

• 回复：胆固醇看来的确是被冤枉了 -clz9876- ♂ (53 bytes) () 05/23/2013 postreply 15:27:56

• 没错，有研究显示低胆固醇增加患癌症的概率 -ERommel- ♂ (561 bytes) () 05/23/2013 postreply 17:58:30

• 科学就是扯蛋，所以公开发表，也没知识产权 -善念真言- ♂ (0 bytes) () 05/24/2013 postreply 05:54:53

• 也不能这么说，真正的科学还是能为人类服务的 -ERommel- ♂ (0 bytes) () 05/24/2013 postreply 19:14:17

• 真正的科学其实是神学，能为人类服务的科学也没知识产权，真正的能为人类服务的是技术 -善念真言- ♂ (0 bytes) () 05/24/2013 postreply 19:48:12

• 科技常常是混在一起说的，但是科学多指对一些现象本质的认知，技术则是用这些认知去实现一些功能。 -这个星球有点轴- ♂ (0 bytes) () 05/25/2013 postreply 08:20:55

• 科学多指对一些现象的解释，技术则是利用这些现象，跟科学解释无关 -善念真言- ♂ (0 bytes) () 05/25/2013 postreply 15:57:02

• 不可能和解释无关吧？简单粗放的技术可以直接来源于现象，稍微复杂一些的技术则恐怕需要用解释所产生原理来计算和辅助设计了。 -这个星球有点轴- ♂ (0 bytes) () 05/25/2013 postreply 18:26:38

• 我说过了，因为你也说过了，科学没你说的那么牛，也没我说的那么不牛，市场价值为零 -善念真言- ♂ (0 bytes) () 05/26/2013 postreply 16:56:04

• 扯蛋倒说不上，更多的只是认识还不够充分或发生了错误而矣。这类认知的东西，本也不需要产权。 -这个星球有点轴- ♂ (0 bytes) () 05/25/2013 postreply 08:22:51

• 科学倒也说不上，认识永远也不够充分，只是近似而矣。这类解释的东西，本没价值。 -善念真言- ♂ (0 bytes) () 05/25/2013 postreply 15:58:53

• 技术也是不断改进，无限优化而矣，根据实践和新的解释优化，产生新的价值，所以解释的价值是通过技术实现的罢了~~ -这个星球有点轴- ♂ (0 bytes) () 05/25/2013 postreply 18:29:32

• 不管怎么说，市场不给它价值，得国家出钱搞科学研究 -善念真言- ♂ (0 bytes) () 05/26/2013 postreply 16:57:01