有这种说法。不过，个人认为这可以用运动员做类比：适量运动有益，过量则是伤害。找到的文献似乎不是巴斯大学的

来源: 吃与活于 2018-02-13 06:57:50 [博客] [旧帖] [给我悄悄话] 本文已被阅读：次

2016 Jan 13;11(1):e0145753. doi: 10.1371/journal.pone.0145753. eCollection 2016.

Evidence for the Cost of Reproduction in Humans: High Lifetime Reproductive Effort Is Associated with Greater Oxidative Stress in Post-Menopausal Women.

Ziomkiewicz A^1,², Sancilio A², Galbarczyk A³, Klimek M³, Jasienska G^2,³, Bribiescas RG².

Author information

1: Anthropology Unit in Wroclaw, Polish Academy of Sciences, Wroclaw, Poland.
2: Department of Anthropology, Yale University, New Haven, Connecticut, United States of America.
3: Department of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.

Abstract

Life history theory predicts trade-offs between reproductive effort and maternal survivorship in energy-restricted environments. However, empirical evidence for the positive association between maternal mortality and reproductive effort from energetically challenged human populations are mixed and physiological mechanisms that may underlie this association are poorly understood. We hypothesized that increases in aerobic metabolism during repeated periods of pregnancy and lactation result in increased oxidative stress that may contribute to somatic deterioration, vulnerability to illness, and accelerated aging. We therefore predicted that lifetime gravidity and parity would be related to levels of biomarkers of oxidative stress, as well as antioxidative defence enzymes in post-menopausal women. Our hypothesis was supported by positive linear associations between levels of 8-OHdG, a biomarker of DNA oxidative damage (β = 0.21, p<0.05), levels of antioxidative defence enzyme Cu-Zn SOD (β = 0.25, p<0.05), and number of lifetime pregnancies. Furthermore, independent of age and health status, post-menopausal women with higher gravidity and parity (> = 4 pregnancies per lifetime) had 20% higher levels of 8-OHdG and 60% higher levels of Cu-Zn SOD compared to women with lower gravidity and parity (<4 pregnancies per lifetime). Our results present the first evidence for oxidative stress as a possible cost of reproductive effort in humans.

PMID:: 26761206
PMCID:: PMC4711894
DOI:: 10.1371/journal.pone.0145753

[Indexed for MEDLINE]

Free PMC Article

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The cost of reproduction in women: Reproductive effort and oxidative stress in premenopausal and postmenopausal American women.

Ziomkiewicz A, Frumkin A, Zhang Y, Sancilio A, Bribiescas RG.

Am J Hum Biol. 2018 Jan;30(1). doi: 10.1002/ajhb.23069. Epub 2017 Oct 6.

PMID:: 28984395