黄芪多糖:糖尿病预防的有效治疗方法。

来源: 2017-07-07 08:09:53 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读: 次 (4595 bytes)
 
 
 
Exp Clin Endocrinol Diabetes. 2008 Aug;116(8):468-74.

Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice.

Abstract

BACKGROUND:

Type 1 diabetes mellitus (DM) is a chronic autoimmune disease that is related to the disequilibrium state of Th1 and Th2 subgroups of helper T lymphocyte (Th) and their cytokines. Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of human immune system.

OBJECTIVE:

To investigate the effects of APS on preventing type 1 DM and Th1/Th2-subtype cytokines, we compared the results of administration of APS and normal saline (NS) on non-obese diabetic (NOD) mice.

SUBJECTS AND METHODS:

APS or NS was administered to 4-week-old mice at a dose of 2.0 g/kg per day for 10 weeks. At 40 weeks, blood glucose, serum C-peptide (C-P) and GAD antibody were measured; pancreas was examined histologically; the intra-islet lymphocyte infiltration and T lymphocyte subsets in the spleen were analysed; the gene expression of IL-1 beta, IL-2, IL-6, IL-12, TNF-alpha, INF-gamma, IL-4, IL-5, IL-10, TGF-beta, Bcl-2, SOD, Fas and iNOS were measured by RT-PCR.

RESULTS:

The results showed that APS-administered NOD mice had a lower incidence rate of type 1 DM, lower serum C-P level, better histologic findings of pancreatic islets, and a lower D4+/CD8+ ratio of T lymphocytes from the spleen and the infiltrated islets. RT-PCR analysis showed gene expression levels are lower in IL-1 beta, IL-2, IL-6, IL-12, TNF-alpha, INF-gamma, Fas, iNOS, and higher in IL-4, IL-5, IL-10, TGF-beta, Bcl-2, SOD in the pancreatic tissue from APS-administered NOD mice as compared to the NS group.

CONCLUSIONS:

These results demonstrated the effects of Astragalus polysaccharides on the prevention of type 1 DM in NOD mice by correcting the imbalance between the Th1/Th2 cytokines.

https://www.ncbi.nlm.nih.gov/pubmed/18924264

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支持御醫的分享 -Lilac2003- 给 Lilac2003 发送悄悄话 Lilac2003 的博客首页 Lilac2003 的个人群组 (0 bytes) () 07/07/2017 postreply 08:12:05

这个黄芪多糖比黄芪泡水还好吗?夏天可以吃吗? -claude888- 给 claude888 发送悄悄话 claude888 的个人群组 (0 bytes) () 07/07/2017 postreply 11:12:54

搜索,御醫高見都在here -Lilac2003- 给 Lilac2003 发送悄悄话 Lilac2003 的博客首页 Lilac2003 的个人群组 (171 bytes) () 07/07/2017 postreply 11:38:45

谢谢 -claude888- 给 claude888 发送悄悄话 claude888 的个人群组 (0 bytes) () 07/07/2017 postreply 13:42:34

有的人喝黄芪片会上火。。。 -御用文人- 给 御用文人 发送悄悄话 御用文人 的个人群组 (332 bytes) () 07/07/2017 postreply 12:40:04

谢谢 -claude888- 给 claude888 发送悄悄话 claude888 的个人群组 (0 bytes) () 07/07/2017 postreply 13:42:51

那里生产的?很怕里面掺其他西药成分。 -goingplace- 给 goingplace 发送悄悄话 goingplace 的博客首页 goingplace 的个人群组 (0 bytes) () 07/07/2017 postreply 11:30:24

Now 是一个好品牌 -Lilac2003- 给 Lilac2003 发送悄悄话 Lilac2003 的博客首页 Lilac2003 的个人群组 (0 bytes) () 07/07/2017 postreply 11:40:06

想种这个,英文叫啥?也叫Astragalus polysaccharides 吗? -xiaoxiao2013- 给 xiaoxiao2013 发送悄悄话 xiaoxiao2013 的个人群组 (0 bytes) () 07/07/2017 postreply 12:17:21

Astragalus membranaceus or Astragalus mongholicus -御用文人- 给 御用文人 发送悄悄话 御用文人 的个人群组 (0 bytes) () 07/07/2017 postreply 12:27:44

thanks :) -xiaoxiao2013- 给 xiaoxiao2013 发送悄悄话 xiaoxiao2013 的个人群组 (0 bytes) () 07/07/2017 postreply 13:51:13

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